Signal Transduction Antibodies 3

Anti-TFIP11 Antibody (CAB9000)

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SKU:
CAB9000
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-TFIP11 Antibody
Antibody SKU:CAB9000
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human TFIP11 (NP_036275.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:3000
Reactivity:Human, Mouse
Positive Samples:LO2, HeLa, A-431, MCF7, HT-1080, Mouse brain, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human TFIP11 (NP_036275.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSLS HLYR DGEG RIDD DDDE RENF EITD WDLQ NEFN PNRQ RHWQ TKEE ATYG VWAE RDSD DERP SFGG KRAR DYSA PVNF ISAG LKKG AAEE AELE DSDD EEKP VKQD DFPK DFGP RKLK TGGN FKPS QKGF AGGT KSFM
Gene ID:24144
Uniprot:Q9UBB9
Cellular Location:Cytoplasm, Nucleus
Calculated MW:22kDa/96kDa
Observed MW:110kDa
Synonyms:TFIP11, NTR1, STIP, STIP-1, Spp382, TIP39, bK445C9.6, hNtr1
Background:
UniProt Protein Function:Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
NCBI Summary:This gene encodes a protein component of the spliceosome that promotes the release of the lariat-intron during late-stage splicing through the recruitment of a pre-mRNA splicing factor called DEAH-box helicase 15. The encoded protein contains a G-patch domain, a hallmark of RNA-processing proteins, that binds DEAH-box helicase 15. This protein contains an atypical nuclear localization sequence as well as a nuclear speckle-targeting sequence, enabling it to localize to distinct speckled regions within the cell nucleus. Polymorphisms in this gene are associated with dental caries suggesting a role in amelogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
UniProt Code:Q9UBB9
NCBI GenInfo Identifier:56788356
NCBI Gene ID:24144
NCBI Accession:NP_001008697.1
UniProt Secondary Accession:Q9UBB9,O95908, Q20WL0, Q5H8V8, Q9UGV7, Q9Y2Q8,
UniProt Related Accession:Q9UBB9
Molecular Weight:22,431 Da
NCBI Full Name:tuftelin-interacting protein 11 isoform 1
NCBI Synonym Full Names:tuftelin interacting protein 11
NCBI Official Symbol:TFIP11  
NCBI Official Synonym Symbols:NTR1; STIP; TIP39; STIP-1; Spp382; bK445C9.6  
NCBI Protein Information:tuftelin-interacting protein 11
UniProt Protein Name:Tuftelin-interacting protein 11
UniProt Synonym Protein Names:Septin and tuftelin-interacting protein 1; STIP-1
UniProt Gene Name:TFIP11  
Anti-TFIP11 Polyclonal Antibody (CAB9000)Western blot analysis of extracts of various cell lines, using TFIP11 antibody (CAB9000) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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