Cell Biology Antibodies 11
Anti-TFG Antibody (CAB7769)
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- SKU:
- CAB7769
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TFG Antibody |
| Antibody SKU: | CAB7769 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human TFG (NP_006061.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, U-251MG, HeLa, HepG2, 293T, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human TFG (NP_006061.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MNGQ LDLS GKLI IKAQ LGED IRRI PIHN EDIT YDEL VLMM QRVF RGKL LSND EVTI KYKD EDGD LITI FDSS DLSF AIQC SRIL KLTL FVNG QPRP LESS QVKY LRRE LIEL RNKV NRLL DSLE PPGE PGPS TNIP ENDT VDGR EEKS ASDS SGKQ STQV MAAS MSAF DPLK NQDE INKN VMSA FGLT DDQV SGPP SAPA EDRS GTPD SIAS SSSA AHPP GVQP QQPP YTGA QTQA GQIE |
| Gene ID: | 10342 |
| Uniprot: | Q92734 |
| Cellular Location: | |
| Calculated MW: | 30kDa/31kDa/43kDa |
| Observed MW: | 55kDa |
| Synonyms: | TFG, HMSNP, SPG57, TF6, TRKT3 |
| Background: | There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. |
| UniProt Protein Function: | TFG: Defects in TFG are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving TFG is found in thyroid papillary carcinomas. Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3'-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript. |
| UniProt Protein Details: | Protein type:Oncoprotein; Adaptor/scaffold Chromosomal Location of Human Ortholog: 3q12.2 Cellular Component: cytosol Molecular Function:protein binding; signal transducer activity Biological Process: COPII coating of Golgi vesicle; positive regulation of I-kappaB kinase/NF-kappaB cascade Disease: Neuropathy, Hereditary Motor And Sensory, Okinawa Type; Spastic Paraplegia 57, Autosomal Recessive |
| NCBI Summary: | There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010] |
| UniProt Code: | Q92734 |
| NCBI GenInfo Identifier: | 223634676 |
| NCBI Gene ID: | 10342 |
| NCBI Accession: | Q92734.2 |
| UniProt Secondary Accession: | Q92734,Q15656, Q969I2, D3DN49, G5E9V1, K0J5S8, K0J6K2 |
| UniProt Related Accession: | Q92734 |
| Molecular Weight: | 30,921 Da |
| NCBI Full Name: | Protein TFG |
| NCBI Synonym Full Names: | TRK-fused gene |
| NCBI Official Symbol: | TFG |
| NCBI Official Synonym Symbols: | TF6; HMSNP; SPG57; TRKT3 |
| NCBI Protein Information: | protein TFG |
| UniProt Protein Name: | Protein TFG |
| UniProt Synonym Protein Names: | TRK-fused gene protein |
| Protein Family: | Protein |
| UniProt Gene Name: | TFG |
| UniProt Entry Name: | TFG_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TFG antibody (CAB7769) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 30s. |
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