KO Validated Antibodies 2

Anti-TFG Antibody (CAB19858)[KO Validated]

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SKU:
CAB19858
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TFG Antibody [KO Validated]
Antibody SKU:CAB19858
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of human TFG.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa
Immunogen:Recombinant protein of human TFG.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10342
Uniprot:Q92734
Cellular Location:
Calculated MW:30kDa/31kDa/43kDa
Observed MW:50KDa
Anti-TFG Antibody [KO Validated] (CAB19858)Western blot analysis of extracts from normal (control) and TFG knockout (KO) HeLa cells, using TFG antibody (CAB19858) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Synonyms:TFG, HMSNP, SPG57, TF6, TRKT3
Background:There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene.
UniProt Protein Function:TFG: Defects in TFG are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving TFG is found in thyroid papillary carcinomas. Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3'-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript.
UniProt Protein Details:

Protein type:Oncoprotein; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 3q12.2

Cellular Component: cytosol

Molecular Function:protein binding; signal transducer activity

Biological Process: COPII coating of Golgi vesicle; positive regulation of I-kappaB kinase/NF-kappaB cascade

Disease: Neuropathy, Hereditary Motor And Sensory, Okinawa Type; Spastic Paraplegia 57, Autosomal Recessive

NCBI Summary:There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
UniProt Code:Q92734
NCBI GenInfo Identifier:223634676
NCBI Gene ID:10342
NCBI Accession:Q92734.2
UniProt Secondary Accession:Q92734,Q15656, Q969I2, D3DN49, G5E9V1, K0J5S8, K0J6K2
UniProt Related Accession:Q92734
Molecular Weight:30,921 Da
NCBI Full Name:Protein TFG
NCBI Synonym Full Names:TRK-fused gene
NCBI Official Symbol:TFG  
NCBI Official Synonym Symbols:TF6; HMSNP; SPG57; TRKT3  
NCBI Protein Information:protein TFG
UniProt Protein Name:Protein TFG
UniProt Synonym Protein Names:TRK-fused gene protein
Protein Family:Protein
UniProt Gene Name:TFG  
UniProt Entry Name:TFG_HUMAN
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