Cell Cycle Antibodies 1

Anti-TFDP2 Antibody (CAB4152)

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SKU:
CAB4152
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-TFDP2 Antibody
Antibody SKU:CAB4152
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 287-386 of human TFDP2 (NP_006277.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse heart, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 287-386 of human TFDP2 (NP_006277.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GYIT DIST GPSW LNQG LLLN STQS VSNL DLTT GATL PQSS VNQG LCLD AEVA LATG QFLA PNSH QSSS AASH CSES RGET PCSF NDED EEDD EEDS SSPE
Gene ID:7029
Uniprot:Q14188
Cellular Location:Nucleus
Calculated MW:34kDa/39kDa/40kDa/41kDa/42kDa/46kDa/49kDa
Observed MW:50kDa
Synonyms:TFDP2, DP2
Background:The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:TFDP2: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and apoptosis. Belongs to the E2F/DP family. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 3q23

Cellular Component: nucleoplasm; transcription factor complex

Molecular Function:protein domain specific binding; DNA binding; transcription cofactor activity; transcription factor binding; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; Notch signaling pathway; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; gene expression; mitotic cell cycle

NCBI Summary:The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
UniProt Code:Q14188
NCBI GenInfo Identifier:8039810
NCBI Gene ID:7029
NCBI Accession:Q14188.2
UniProt Related Accession:Q14188
Molecular Weight:
NCBI Full Name:Transcription factor Dp-2
NCBI Synonym Full Names:transcription factor Dp-2
NCBI Official Symbol:TFDP2  
NCBI Official Synonym Symbols:DP2  
NCBI Protein Information:transcription factor Dp-2
UniProt Protein Name:Transcription factor Dp-2
UniProt Synonym Protein Names:E2F dimerization partner 2
UniProt Gene Name:TFDP2  
UniProt Entry Name:TFDP2_HUMAN
Anti-TFDP2 Antibody (CAB4152)Western blot analysis of extracts of various cell lines, using TFDP2 antibody (CAB4152) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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