Epigenetics & Nuclear Signaling Antibodies 3
Anti-TFCP2 Antibody (CAB5555)
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- SKU:
- CAB5555
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-TFCP2 Antibody |
| Antibody SKU: | CAB5555 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human TFCP2 (NP_005644.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | BT-474, THP-1, SKOV3, K-562, Mouse kidney, Mouse brain, Mouse testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human TFCP2 (NP_005644.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAWA LKLP LADE VIES GLVQ DFDA SLSG IGQE LGAG AYSM SDVL ALPI FKQE ESSL PPDN ENKI LPFQ YVLC AATS PAVK LHDE TLTY LNQG QSYE IRML DNRK LGEL PEIN GKLV KSIF RVVF HDRR LQYT EHQQ LEGW RWNR PGDR ILDI DIPM SVGI IDPR ANPT QLNT VEFL WDPA KRTS VFIQ VHCI STEF TMRK HGGE KGVP FRVQ IDTF KENE NGEY TEHL HSAS CQIK VFKP KGAD RKQK TDRE KMEK RTPH EKEK YQPS YETT ILTE CSPW |
| Gene ID: | 7024 |
| Uniprot: | Q12800 |
| Cellular Location: | Nucleus |
| Calculated MW: | 51kDa/57kDa |
| Observed MW: | 64kDa |
| Synonyms: | TFCP2, LBP1C, LSF, LSF1D, SEF, TFCP2C |
| Background: | This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease. |
| UniProt Protein Function: | TFCP2: Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1. Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter. Belongs to the grh/CP2 family. CP2 subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 12q13 Cellular Component: nucleus Molecular Function:DNA binding; sequence-specific DNA binding; transcription factor activity Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease. [provided by RefSeq, Mar 2010] |
| UniProt Code: | Q12800 |
| NCBI GenInfo Identifier: | 90101767 |
| NCBI Gene ID: | 7024 |
| NCBI Accession: | Q12800.2 |
| UniProt Secondary Accession: | Q12800,Q12801, Q9UD75, Q9UD77, A8K5E9, |
| UniProt Related Accession: | Q12800,AAB29976 |
| Molecular Weight: | 502 |
| NCBI Full Name: | Alpha-globin transcription factor CP2 |
| NCBI Synonym Full Names: | transcription factor CP2 |
| NCBI Official Symbol: | TFCP2 |
| NCBI Official Synonym Symbols: | LSF; SEF; LBP1C; LSF1D; TFCP2C |
| NCBI Protein Information: | alpha-globin transcription factor CP2; SAA3 enhancer factor |
| UniProt Protein Name: | Alpha-globin transcription factor CP2 |
| UniProt Synonym Protein Names: | SAA3 enhancer factor; Transcription factor LSF |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | TFCP2 |
| UniProt Entry Name: | TFCP2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TFCP2 antibody (CAB5555) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Basic Kit (RM00020)._Exposure time: 5s. |
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