Epigenetics & Nuclear Signaling Antibodies 2

Anti-TFB2M Antibody (CAB14921)

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SKU:
CAB14921
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-TFB2M Antibody
Antibody SKU:CAB14921
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-396 of human TFB2M (NP_071761.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-396 of human TFB2M (NP_071761.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AGRF CILG SEAA TRKH LPAR NHCG LSDS SPQL WPEP DFRN PPRK ASKA SLDF KRYV TDRR LAET LAQI YLGK PSRP PHLL LECN PGPG ILTQ ALLE AGAK VVAL ESDK TFIP HLES LGKN LDGK LRVI HCDF FKLD PRSG GVIK PPAM SSRG LFKN LGIE AVPW TADI PLKV VGMF PSRG EKRA LWKL AYDL YSCT SIYK FGRI EVNM FIGE KEFQ KLMA DPGN PDLY HVLS VIWQ LACE IKVL HMEP WSSF DIYT RKGP LENP KRRE LLDQ LQQK LYLI QMIP RQNL FTKN LTPM NYNI FFHL LKHC FGRR SATV IDHL RSLT PLDA RDIL MQIG KQED EKVV NMHP QDFK TLFE TIER SKDC AYKW LYDE TLED R
Gene ID:64216
Uniprot:Q9H5Q4
Cellular Location:Mitochondrion
Calculated MW:45kDa
Observed MW:Refer to figures
Synonyms:TFB2M, Hkp1, mtTFB2
Background:
UniProt Protein Function:TFB2M: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity. Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
UniProt Protein Details:

Protein type:EC 2.1.1.-; Methyltransferase; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1q44

Cellular Component: mitochondrial matrix

Molecular Function:rRNA (adenine-N6,N6-)-dimethyltransferase activity; transcription cofactor activity

Biological Process: mitochondrion organization and biogenesis; positive regulation of transcription, DNA-dependent; organelle organization and biogenesis; rRNA methylation; gene expression; transcription from mitochondrial promoter; transcription initiation from mitochondrial promoter

UniProt Code:Q9H5Q4
NCBI GenInfo Identifier:11641289
NCBI Gene ID:64216
NCBI Accession:NP_071761.1
UniProt Related Accession:Q9H5Q4
Molecular Weight:45kDa
NCBI Full Name:dimethyladenosine transferase 2, mitochondrial
NCBI Synonym Full Names:transcription factor B2, mitochondrial
NCBI Official Symbol:TFB2M  
NCBI Official Synonym Symbols:Hkp1; mtTFB2  
NCBI Protein Information:dimethyladenosine transferase 2, mitochondrial
UniProt Protein Name:Dimethyladenosine transferase 2, mitochondrial
UniProt Synonym Protein Names:Hepatitis C virus NS5A-transactivated protein 5; HCV NS5A-transactivated protein 5; Mitochondrial 12S rRNA dimethylase 2; Mitochondrial transcription factor B2; h-mtTFB; h-mtTFB2; hTFB2M; mtTFB2; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2
Protein Family:Dimethyladenosine transferase
UniProt Gene Name:TFB2M  
UniProt Entry Name:TFB2M_HUMAN
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