Epigenetics & Nuclear Signaling Antibodies 4
Anti-TFAP2C Antibody (CAB7739)
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- SKU:
- CAB7739
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-TFAP2C Antibody |
| Antibody SKU: | CAB7739 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human TFAP2C |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat, SW620, Raji, Mouse skeletal muscle |
| Immunogen: | A synthetic peptide of human TFAP2C |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7022 |
| Uniprot: | Q92754 |
| Cellular Location: | Nucleus |
| Calculated MW: | 31kDa/49kDa |
| Observed MW: | 49kDa |
| Synonyms: | TFAP2C, AP2-GAMMA, ERF1, TFAP2G, hAP-2g |
| Background: | The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. |
| UniProt Protein Function: | AP-2 gamma: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. During retinoic acid-mediated differentiation. Belongs to the AP-2 family. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 20q13.2 Cellular Component: mitochondrion; nucleoplasm; nucleus Molecular Function:DNA binding; protein binding; protein dimerization activity; transcription factor activity Biological Process: cell-cell signaling; male gonad development; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; regulation of gene expression, epigenetic; regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92754 |
| NCBI GenInfo Identifier: | 12643310 |
| NCBI Gene ID: | 7022 |
| NCBI Accession: | Q92754.1 |
| UniProt Secondary Accession: | Q92754,O00685, O00730, Q86V30, Q8IVB6, Q9P1X2, B4DWK3 |
| UniProt Related Accession: | Q92754 |
| Molecular Weight: | 31,010 Da |
| NCBI Full Name: | Transcription factor AP-2 gamma |
| NCBI Synonym Full Names: | transcription factor AP-2 gamma |
| NCBI Official Symbol: | TFAP2C |
| NCBI Official Synonym Symbols: | ERF1; TFAP2G; hAP-2g; AP2-GAMMA |
| NCBI Protein Information: | transcription factor AP-2 gamma |
| UniProt Protein Name: | Transcription factor AP-2 gamma |
| UniProt Synonym Protein Names: | Activating enhancer-binding protein 2 gamma; Transcription factor ERF-1 |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | TFAP2C |
| UniProt Entry Name: | AP2C_HUMAN |
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