Epigenetics & Nuclear Signaling Antibodies 1
Anti-TFAP2B Antibody (CAB13885)
- SKU:
- CAB13885
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-TFAP2B Antibody |
| Antibody SKU: | CAB13885 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human TFAP2B (NP_003212.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human TFAP2B (NP_003212.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MHSP PRDQ AAIM LWKL VENV KYED IYED RHDG VPSH SSRL SQLG SVSQ GPYS SAPP LSHT PSSD FQPP YFPP PYQP LPYH QSQD PYSH VNDP YSLN PLHQ PQQH PWGQ RQRQ EVGS EAGS LLPQ PRAA LPQL SGLD PRRD YHSV RRPD VLLH SAHH GLDA |
| Gene ID: | 7021 |
| Uniprot: | Q92481 |
| Cellular Location: | Nucleus |
| Calculated MW: | 50kDa/51kDa |
| Observed MW: | 45kDa |
| Synonyms: | TFAP2B, AP-2B, AP2-B, PDA2 |
| Background: | This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. |
| UniProt Protein Function: | AP-2 beta: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. Belongs to the AP-2 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 6p12 Cellular Component: nucleus Molecular Function:caspase inhibitor activity; DNA binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; transcription coactivator activity; transcription corepressor activity; transcription factor activity Biological Process: calcium ion homeostasis; fat cell differentiation; forelimb morphogenesis; glucose homeostasis; glucose metabolic process; hindlimb morphogenesis; kidney development; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; phosphate ion homeostasis; positive regulation of cell proliferation; positive regulation of neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; potassium ion homeostasis; regulation of BMP signaling pathway; regulation of cell differentiation; regulation of insulin secretion; regulation of transcription, DNA-dependent; renal water homeostasis; sodium ion homeostasis; sympathetic nervous system development Disease: Char Syndrome |
| NCBI Summary: | This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92481 |
| NCBI GenInfo Identifier: | 152031557 |
| NCBI Gene ID: | 7021 |
| NCBI Accession: | Q92481.2 |
| UniProt Secondary Accession: | Q92481,Q5JYX6, Q9NQ63, Q9NU99, Q9UJI7, Q9Y214, Q9Y3K3 |
| UniProt Related Accession: | Q92481 |
| Molecular Weight: | 51,524 Da |
| NCBI Full Name: | Transcription factor AP-2-beta |
| NCBI Synonym Full Names: | transcription factor AP-2 beta |
| NCBI Official Symbol: | TFAP2B |
| NCBI Official Synonym Symbols: | PDA2; AP-2B; AP2-B |
| NCBI Protein Information: | transcription factor AP-2-beta |
| UniProt Protein Name: | Transcription factor AP-2-beta |
| UniProt Synonym Protein Names: | Activating enhancer-binding protein 2-beta |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | TFAP2B |
| UniProt Entry Name: | AP2B_HUMAN |
 | Western blot analysis of extracts of mouse skeletal muscle, using TFAP2B antibody (CAB13885) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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