Cell Biology Antibodies 4
Anti-TET3 Antibody (CAB13453)
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- SKU:
- CAB13453
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TET3 Antibody |
| Antibody SKU: | CAB13453 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1556-1795 of human TET3 (NP_001274420.1). |
| Application: | IHC IF |
| Recommended Dilution: | IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1556-1795 of human TET3 (NP_001274420.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LWNP MKGE EGRI PAAG ASQL DRAW QSFG LPLG SSEK LFGA LKSE EKLW DPFS LEEG PAEE PPSK GAVK EEKG GGGA EEEE EELW SDSE HNFL DENI GGVA VAPA HGSI LIEC ARRE LHAT TPLK KPNR CHPT RISL VFYQ HKNL NQPN HGLA LWEA KMKQ LAER ARAR QEEA ARLG LGQQ EAKL YGKK RKWG GTVV AEPQ QKEK KGVV PTRQ ALAV PTDS AVTV SSYA YTKV TGPY SRWI |
| Gene ID: | 200424 |
| Uniprot: | O43151 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 77kDa/166kDa/179kDa |
| Observed MW: |
| Synonyms: | TET3, hCG_40738, TET3 |
| Background: |
| UniProt Protein Function: | TET3: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Conversion into 5hmC initiates a process leading to cytosine demethylation through deamination into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin. Belongs to the TET family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 1.14.11.n2; Oxidoreductase Chromosomal Location of Human Ortholog: 2p13.1 Cellular Component: male pronucleus; cytoplasm; female pronucleus Molecular Function:protein binding; DNA binding; metal ion binding Biological Process: protein amino acid O-linked glycosylation; gene expression; positive regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic |
| NCBI Summary: | Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009 [PubMed 19923888]).[supplied by OMIM, Nov 2010] |
| UniProt Code: | O43151 |
| NCBI GenInfo Identifier: | 190358928 |
| NCBI Gene ID: | 200424 |
| NCBI Accession: | O43151.3 |
| UniProt Secondary Accession: | O43151,Q86Z24, Q8TBM9, A6NEI3, |
| UniProt Related Accession: | O43151 |
| Molecular Weight: | Calculated MW: 77kDa/166kDa/179kDaObserved MW: 200kDa |
| NCBI Full Name: | Methylcytosine dioxygenase TET3 |
| NCBI Synonym Full Names: | tet methylcytosine dioxygenase 3 |
| NCBI Official Symbol: | TET3 |
| NCBI Official Synonym Symbols: | hCG_40738 |
| NCBI Protein Information: | methylcytosine dioxygenase TET3 |
| UniProt Protein Name: | Methylcytosine dioxygenase TET3 |
| Protein Family: | Tetraspanin |
| UniProt Gene Name: | TET3 |
| UniProt Entry Name: | TET3_HUMAN |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using TET3 antibody (CAB13453) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human appendix using TET3 antibody (CAB13453) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of A549 cells using TET3 antibody (CAB13453). Blue: DAPI for nuclear staining. |
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