Epigenetics & Nuclear Signaling Antibodies 2
Anti-TET1 Antibody (CAB1506)
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- SKU:
- CAB1506
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-TET1 Antibody |
| Antibody SKU: | CAB1506 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human TET1 |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-431 |
| Immunogen: | Recombinant protein of human TET1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 80312 |
| Uniprot: | Q8NFU7 |
| Cellular Location: | Nucleus |
| Calculated MW: | 235kDa |
| Observed MW: | 235kDa |
| Synonyms: | TET1, CXXC6, LCX, bA119F7.1, MLL-TET1, TET1-MLL |
| Background: | DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET protein family play a role in the DNA methylation process and gene activation. |
| UniProt Protein Function: | TET1: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC). Might initiate a process leading to cytosine demethylation through deamination into 5- hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and polycomb-repressed genes. By controlling the levels of 5mC and 5hmC at gene promoters, it may regulate the gene expression silencing induced by cytosine methylation. May have a dual function by also repressing the expression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification. A chromosomal aberration involving TET1 may be a cause of acute leukemias. Translocation t(10;11)(q22;q23) with MLL. This is a rare chromosomal translocation 5' MLL-TET1 3'. Belongs to the TET family. |
| UniProt Protein Details: | Protein type:Oxidoreductase; DNA-binding; EC 1.14.11.n2 Chromosomal Location of Human Ortholog: 10q21 Cellular Component: nucleus Molecular Function:structure-specific DNA binding; zinc ion binding; iron ion binding Biological Process: protein amino acid O-linked glycosylation; inner cell mass cell differentiation; transcription, DNA-dependent; stem cell maintenance; positive regulation of transcription from RNA polymerase II promoter; gene expression; chromatin modification; regulation of gene expression, epigenetic |
| NCBI Summary: | DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET protein family play a role in the DNA methylation process and gene activation. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q8NFU7 |
| NCBI GenInfo Identifier: | 115502139 |
| NCBI Gene ID: | 80312 |
| NCBI Accession: | Q8NFU7.2 |
| UniProt Related Accession: | Q8NFU7 |
| Molecular Weight: | |
| NCBI Full Name: | Methylcytosine dioxygenase TET1 |
| NCBI Synonym Full Names: | tet methylcytosine dioxygenase 1 |
| NCBI Official Symbol: | TET1 |
| NCBI Official Synonym Symbols: | LCX; CXXC6; bA119F7.1 |
| NCBI Protein Information: | methylcytosine dioxygenase TET1 |
| UniProt Protein Name: | Methylcytosine dioxygenase TET1 |
| UniProt Synonym Protein Names: | CXXC-type zinc finger protein 6; Leukemia-associated protein with a CXXC domain; Ten-eleven translocation 1 gene protein |
| Protein Family: | Methylcytosine dioxygenase |
| UniProt Gene Name: | TET1 |
| UniProt Entry Name: | TET1_HUMAN |
 | Western blot analysis of extracts of A-431 cells, using TET1 antibody (CAB1506). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded mouse spleen using TET1 antibody (CAB1506) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse testis using TET1 antibody (CAB1506) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of HeLa cells using TET1 Polyclonal Antibody (CAB1506) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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