Cell Biology Antibodies 3

Anti-TESK2 Antibody (CAB13395)

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SKU:
CAB13395
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TESK2 Antibody
Antibody SKU:CAB13395
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 302-571 of human TESK2 (NP_009101.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:Mouse liver, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 302-571 of human TESK2 (NP_009101.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FVEI GKTL EEIL SRLQ EEEQ ERDR KLQP TARG LLEK APGV KRLS SLDD KIPH KSPC PRRT IWLS RSQS DIFS RKPP RTVS VLDP YYRP RDGA ARTP KVNP FSAR QDLM GGKI KFFD LPSK SVIS LVFD LDAP GPGT MPLA DWQE PLAP PIRR WRSL PGSP EFLH QEAC PFVG REES LSDG PPPR LSSL KYRV KEIP PFRA SALP AAQA HEAM DCSI LQEE NGFG SRPQ GTSP CPAG ASEE MEVE ERPA GSTP ATFS TSGI GLQT QGKQ DG
Gene ID:10420
Uniprot:Q96S53
Cellular Location:Nucleus
Calculated MW:60kDa/61kDa/63kDa
Observed MW:64kDa
Synonyms:TESK2
Background:This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:TESK2: a TKL kinase of the LISK family. Predominantly expressed in testis and prostate. The developmental expression pattern in the testis suggests an important role in meitoic stages and/or early stages of spermiogenesis. Three alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.12.1; TKL group; LISK family; TESK subfamily

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: nucleoplasm; nucleus

Molecular Function:protein binding; protein kinase activity; protein serine/threonine kinase activity

Biological Process: actin cytoskeleton organization and biogenesis; focal adhesion formation; protein amino acid phosphorylation; spermatogenesis

NCBI Summary:This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
UniProt Code:Q96S53
NCBI GenInfo Identifier:25009462
NCBI Gene ID:10420
NCBI Accession:Q96S53.1
UniProt Secondary Accession:Q96S53,Q5T422, Q5T423, Q8N520, Q9Y3Q6,
UniProt Related Accession:Q96S53
Molecular Weight:60,332 Da
NCBI Full Name:Dual specificity testis-specific protein kinase 2
NCBI Synonym Full Names:testis-specific kinase 2
NCBI Official Symbol:TESK2  
NCBI Protein Information:dual specificity testis-specific protein kinase 2
UniProt Protein Name:Dual specificity testis-specific protein kinase 2
UniProt Synonym Protein Names:Testicular protein kinase 2
Protein Family:Dual specificity testis-specific protein kinase
UniProt Gene Name:TESK2  
UniProt Entry Name:TESK2_HUMAN
Anti-TESK2 Antibody (CAB13395)Western blot analysis of extracts of various cell lines, using TESK2 antibody (CAB13395) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 1s.
Anti-TESK2 Antibody (CAB13395)Immunofluorescence analysis of A549 cells using TESK2 antibody (CAB13395). Blue: DAPI for nuclear staining.
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