Cell Cycle Antibodies 1

Anti-TERF1 Antibody (CAB0137)

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SKU:
CAB0137
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-TERF1 Antibody
Antibody SKU:CAB0137
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 240-419 of human TERF1 (NP_003209.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:Mouse eye
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 240-419 of human TERF1 (NP_003209.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IKSY VNYV LSEK SSTF LMKA AAKV VESK RTRT ITSQ DKPS GNDV EMET EANL DTRK RSHK NLFL SKLQ HGTQ QQDL NKKE RRVG TPQS TKKK KESR RATE SRIP VSKS QPVT PEKH RARK RQAW LWEE DKNL RSGV RKYG EGNW SKIL LHYK FNNR TSVM LKDR WRTM KKLK LISS DSED
Gene ID:7013
Uniprot:P54274
Cellular Location:Chromosome, Cytoplasm, Nucleus, cytoskeleton, spindle, telomere
Calculated MW:48kDa/50kDa
Observed MW:62kDa
Synonyms:TERF1, PIN2, TRBF1, TRF, TRF1, hTRF1-AS, t-TRF1
Background:This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products.
UniProt Protein Function:TRF1: a telomeric repeat binding factor. Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Colocalizes with telomeric DNA in interphase and metaphase cells and is located at chromosome ends during metaphase. Involved in the regulation of the mitotic spindle. Expression is tightly regulated during the cell cycle; levels are low in G1 and S phase and increase during G2 phase and mitosis. Two splice variant isoforms have been described.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 8q21.11

Cellular Component: nucleoplasm; chromosome, telomeric region; nuclear telomere cap complex; nuclear chromosome, telomeric region; cytoplasm; nucleolus; spindle; nucleus

Molecular Function:protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; microtubule binding; telomeric DNA binding; double-stranded telomeric DNA binding; chromatin binding; DNA bending activity

Biological Process: response to drug; mitosis; positive regulation of mitosis; negative regulation of telomere maintenance via semi-conservative replication; positive regulation of apoptosis; positive regulation of microtubule polymerization; telomere maintenance via telomerase; positive regulation of mitotic cell cycle; negative regulation of telomerase activity; cell division; negative regulation of DNA replication; telomeric loop formation; mitotic cell cycle spindle assembly checkpoint; age-dependent telomere shortening; G2/M transition of mitotic cell cycle; negative regulation of telomere maintenance via telomerase; telomere maintenance; protein homooligomerization

NCBI Summary:This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008]
UniProt Code:P54274
NCBI GenInfo Identifier:206729904
NCBI Gene ID:7013
NCBI Accession:P54274.3
UniProt Secondary Accession:P54274,Q15553, Q8NHT6, Q93029, A7XP29,
UniProt Related Accession:P54274
Molecular Weight:439
NCBI Full Name:Telomeric repeat-binding factor 1
NCBI Synonym Full Names:telomeric repeat binding factor (NIMA-interacting) 1
NCBI Official Symbol:TERF1  
NCBI Official Synonym Symbols:TRF; PIN2; TRF1; TRBF1; t-TRF1; hTRF1-AS  
NCBI Protein Information:telomeric repeat-binding factor 1; NIMA-interacting protein 2; telomeric protein Pin2/TRF1; TTAGGG repeat-binding factor 1
UniProt Protein Name:Telomeric repeat-binding factor 1
UniProt Synonym Protein Names:NIMA-interacting protein 2; TTAGGG repeat-binding factor 1; Telomeric protein Pin2/TRF1
Protein Family:Telomeric repeat-binding factor
UniProt Gene Name:TERF1  
UniProt Entry Name:TERF1_HUMAN
Anti-TERF1 Antibody (CAB0137)Western blot analysis of extracts of mouse eye, using TERF1 antibody (CAB0137) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-TERF1 Antibody (CAB0137)Immunohistochemistry of paraffin-embedded human gastric cancer using TERF1 antibody (CAB0137) at dilution of 1:200 (40x lens).
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system_update_altDatasheetHuman TERF1/TRF1 Recombinant Protein Telomeric repeat binding factor 1 (TRF1), also known as TERF1, the shelterin complex, which modulates the telomere structures. TRF1