Cell Biology Antibodies 14

Anti-TELO2 Antibody (CAB17064)

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SKU:
CAB17064
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TELO2 Antibody
Antibody SKU:CAB17064
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 450-550 of human TELO2 (NP_057195.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:K-562, HeLa
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 450-550 of human TELO2 (NP_057195.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ASEA GTSL VPAT AEPP AETP AEIV DGGV PQAQ LAGS DSDL DSDD EFVP YDMS GDRE LKSS KAPA YVRD CVEA LTTS EDIE RWEA ALRA LEGL VYRS PTAT R
Gene ID:9894
Uniprot:Q9Y4R8
Cellular Location:
Calculated MW:91kDa
Observed MW:102kDa
Anti-TELO2 Antibody (CAB17064)Western blot - TELO2 Rabbit pAb (CAB17064)
Synonyms:TELO2, CLK2, TEL2, YHFS
Background:This gene encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. The protein may also play a role in DNA repair.
UniProt Protein Function:TELO2: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. Component of the TTT complex composed of TELO2, TTI1 and TTI2. Interacts with ATM, ATR, MTOR, PRKDC, RUVBL2, TTI1, TTI2, SMG1 and TRRAP. Belongs to the TEL2 family.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: chromosome, telomeric region; membrane; cytoplasm; TORC2 complex; intracellular; nucleus

Molecular Function:protein binding; protein complex binding; protein complex scaffold

Biological Process: regulation of TOR signaling pathway

NCBI Summary:This gene encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. The protein may also play a role in DNA repair.[provided by RefSeq, Mar 2009]
UniProt Code:Q9Y4R8
NCBI GenInfo Identifier:166987394
NCBI Gene ID:9894
NCBI Accession:Q9Y4R8.2
UniProt Secondary Accession:Q9Y4R8,O75168, Q7LDV4, Q9BR21, D3DU73,
UniProt Related Accession:Q9Y4R8
Molecular Weight:837
NCBI Full Name:Telomere length regulation protein TEL2 homolog
NCBI Synonym Full Names:telomere maintenance 2
NCBI Official Symbol:TELO2  
NCBI Official Synonym Symbols:CLK2; TEL2  
NCBI Protein Information:telomere length regulation protein TEL2 homolog; protein clk-2 homolog; TEL2, telomere maintenance 2, homolog
UniProt Protein Name:Telomere length regulation protein TEL2 homolog
UniProt Synonym Protein Names:Protein clk-2 homolog; hCLK2
Protein Family:TELO2-interacting protein
UniProt Gene Name:TELO2  
UniProt Entry Name:TELO2_HUMAN
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