Epigenetics & Nuclear Signaling Antibodies 3
Anti-TDP1 Antibody (CAB4849)
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- SKU:
- CAB4849
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- TDP1
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | TDP1 Rabbit pAb |
| Product Code: | CAB4849 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | TDP1 |
| Applications: | WB, IF |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human TDP1 (NP_060789.2). |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Rat |
| Positive Samples: | HL-60, DU145, Rat thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human TDP1 (NP_060789.2). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSQE GDYG RWTI SSSD ESEE EKPK PDKP STSS LLCA RQGA ANEP RYTC SEAQ KAAH KRKI SPVK FSNT DSVL PPKR QKSG SQED LGWC LSSS DDEL QPEM PQKQ AEKV VIKK EKDI SAPN DGTA QRTE NHGA PACH RLKE |
| Gene ID: | 55775 |
| Uniprot: | Q9NUW8 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 41kDa/68kDa |
| Observed MW: | 70kDa |
| UniProt Protein Function: | TDP1: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. Monomer. Ubiquitously expressed. Similar expression throughout the central nervous system (whole brain, amygdala, caudate nucleus, cerebellum, cerebral cortex, frontal lobe, hippocampus, medulla oblongata, occipital lobe, putamen, substantia nigra, temporal lobe, thalamus, nucleus accumbens and spinal cord) and increased expression in testis and thymus. Belongs to the tyrosyl-DNA phosphodiesterase family. |
| UniProt Protein Details: | Protein type:Phosphodiesterase; EC 3.1.4.-; DNA repair, damage Chromosomal Location of Human Ortholog: 14q32.11 Cellular Component: cytoplasm; nucleus Molecular Function:tyrosyl-DNA phosphodiesterase activity; protein binding; double-stranded DNA binding; exonuclease activity; single-stranded DNA binding Biological Process: single strand break repair; double-strand break repair; DNA repair Disease: Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy |
| NCBI Summary: | The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). [provided by RefSeq, Aug 2016] |
| UniProt Code: | Q9NUW8 |
| NCBI GenInfo Identifier: | 37999797 |
| NCBI Gene ID: | 55775 |
| NCBI Accession: | Q9NUW8.2 |
| UniProt Related Accession: | Q9NUW8 |
| Molecular Weight: | Predicted Molecular Mass: 20.4kDaAccurate Molecular Mass: 25kDa |
| NCBI Full Name: | Tyrosyl-DNA phosphodiesterase 1 |
| NCBI Synonym Full Names: | tyrosyl-DNA phosphodiesterase 1 |
| NCBI Official Symbol: | TDP1 |
| NCBI Protein Information: | tyrosyl-DNA phosphodiesterase 1 |
| UniProt Protein Name: | Tyrosyl-DNA phosphodiesterase 1 |
| Protein Family: | Tyrosyl-DNA phosphodiesterase |
| UniProt Gene Name: | TDP1 |
| UniProt Entry Name: | TYDP1_HUMAN |
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