Metabolism Antibodies 2

Anti-TDO2 Antibody (CAB6766)

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SKU:
CAB6766
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-TDO2 Antibody
Antibody SKU:CAB6766
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 137-406 of human TDO2 (NP_005642.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:293T, U-937, SKOV3, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 137-406 of human TDO2 (NP_005642.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ALDF NDFR EYLS PASG FQSL QFRL LENK IGVL QNMR VPYN RRHY RDNF KGEE NELL LKSE QEKT LLEL VEAW LERT PGLE PHGF NFWG KLEK NITR GLEE EFIR IQAK EESE EKEE QVAE FQKQ KEVL LSLF DEKR HEHL LSKG ERRL SYRA LQGA LMIY FYRE EPRF QVPF QLLT SLMD IDSL MTKW RYNH VCMV HRML GSKA GTGG SSGY HYLR STVS DRYK VFVD LFNL STYL IPRH WIPK MNPT IHKF LYTA EYCD SSYF SSDE SD
Gene ID:6999
Uniprot:P48775
Cellular Location:
Calculated MW:47kDa
Observed MW:48kDa
Synonyms:TDO2, TDO, TO, TPH2, TRPO, tryptophan 2
Background:This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.
UniProt Protein Function:TDO2: Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin. Belongs to the tryptophan 2,3-dioxygenase family.
UniProt Protein Details:

Protein type:Amino Acid Metabolism - tryptophan; Oxidoreductase; EC 1.13.11.11

Chromosomal Location of Human Ortholog: 4q31-q32

Cellular Component: cytosol

Molecular Function:heme binding; protein binding; tryptophan 2,3-dioxygenase activity

Biological Process: tryptophan catabolic process; tryptophan catabolic process to acetyl-CoA

NCBI Summary:This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]
UniProt Code:P48775
NCBI GenInfo Identifier:1351188
NCBI Gene ID:6999
NCBI Accession:P48775.1
UniProt Secondary Accession:P48775,A8K053,
UniProt Related Accession:P48775
Molecular Weight:47,872 Da
NCBI Full Name:Tryptophan 2,3-dioxygenase
NCBI Synonym Full Names:tryptophan 2,3-dioxygenase
NCBI Official Symbol:TDO2  
NCBI Official Synonym Symbols:TO; TDO; TPH2; TRPO  
NCBI Protein Information:tryptophan 2,3-dioxygenase
UniProt Protein Name:Tryptophan 2,3-dioxygenase
UniProt Synonym Protein Names:Tryptamin 2,3-dioxygenase
UniProt Gene Name:TDO2  
UniProt Entry Name:T23O_HUMAN
Anti-TDO2 Antibody (CAB6766)Western blot analysis of extracts of various cell lines, using TDO2 antibody (CAB6766) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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