Cell Biology Antibodies 17
Anti-TCP1 beta Antibody (CAB4700)
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- SKU:
- CAB4700
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TCP1 beta Antibody |
| Antibody SKU: | CAB4700 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human TCP1 beta |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Raji, SH-SY5Y, Mouse liver, Mouse testis, Mouse brain, Rat brain |
| Immunogen: | A synthesized peptide derived from human TCP1 beta |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10576 |
| Uniprot: | P78371 |
| Cellular Location: | |
| Calculated MW: | 57kDa |
| Observed MW: | 57KDa |
| Synonyms: | 99D8.1, CCT-beta, CCTB, HEL-S-100n, PRO1633, TCP-1-beta |
| Background: | The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] |
| UniProt Protein Function: | CCT-beta: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Belongs to the TCP-1 chaperonin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Chaperone Chromosomal Location of Human Ortholog: 12q15 Cellular Component: chaperonin-containing T-complex; microtubule; cytoplasm; cytosol Molecular Function:protein binding; ubiquitin protein ligase binding; unfolded protein binding; ATP binding Biological Process: 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; binding of sperm to zona pellucida; chaperone-mediated protein complex assembly |
| NCBI Summary: | The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] |
| UniProt Code: | P78371 |
| NCBI GenInfo Identifier: | 6094436 |
| NCBI Gene ID: | 10576 |
| NCBI Accession: | P78371.4 |
| UniProt Secondary Accession: | P78371,Q14D36, Q6IAT3, A8K402, B5BTY7, B7Z243, B7Z7K4 B7ZAT2, |
| UniProt Related Accession: | P78371 |
| Molecular Weight: | 535 |
| NCBI Full Name: | T-complex protein 1 subunit beta |
| NCBI Synonym Full Names: | chaperonin containing TCP1, subunit 2 (beta) |
| NCBI Official Symbol: | CCT2 |
| NCBI Official Synonym Symbols: | CCTB; 99D8.1; PRO1633; CCT-beta; HEL-S-100n; TCP-1-beta |
| NCBI Protein Information: | T-complex protein 1 subunit beta; T-complex protein 1, beta subunit; epididymis secretory sperm binding protein Li 100n; chaperonin containing t-complex polypeptide 1, subunit 2; chaperonin containing t-complex polypeptide 1, beta subunit |
| UniProt Protein Name: | T-complex protein 1 subunit beta |
| UniProt Synonym Protein Names: | CCT-beta |
| Protein Family: | Choline-phosphate cytidylyltransferase |
| UniProt Gene Name: | CCT2 |
| UniProt Entry Name: | TCPB_HUMAN |
 | Western blot - TCP1 beta Rabbit mAb (CAB4700) |
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