Anti-TCP1 alpha Antibody (CAB3887)
- SKU:
- CAB3887
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CCT-alpha
- Synonyms:
- CCT1
- Synonyms:
- CCTa
- Synonyms:
- D6S230E
- Synonyms:
- TCP-1-alpha
- Research Area:
- Cell Biology
Description
| Product Name: | TCP1 alpha Rabbit mAb |
| Product Code: | CAB3887 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CCT-alpha, CCT1, CCTa, D6S230E, TCP-1-alpha |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human TCP1 alpha |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | Jurkat |
| Immunogen: | A synthesized peptide derived from human TCP1 alpha |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6950 |
| Uniprot: | P17987 |
| Calculated MW: | 60 kDa |
| Observed MW: | 60KDa |
| UniProt Protein Function: | CCT-alpha: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Belongs to the TCP-1 chaperonin family. |
| UniProt Protein Details: | Protein type:Chaperone; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 6q25.3-q26 Cellular Component: chaperonin-containing T-complex; Golgi apparatus; centrosome; microtubule; pericentriolar material; acrosome; nuclear heterochromatin; cytosol Molecular Function:protein binding; ubiquitin protein ligase binding; unfolded protein binding; ATP binding Biological Process: tubulin folding; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; binding of sperm to zona pellucida |
| NCBI Summary: | The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010] |
| UniProt Code: | P17987 |
| NCBI GenInfo Identifier: | 135538 |
| NCBI Gene ID: | 6950 |
| NCBI Accession: | P17987.1 |
| UniProt Secondary Accession: | P17987,Q15556, Q5TCM3, E1P5B2, |
| UniProt Related Accession: | P17987 |
| Molecular Weight: | 556 |
| NCBI Full Name: | T-complex protein 1 subunit alpha |
| NCBI Synonym Full Names: | t-complex 1 |
| NCBI Official Symbol: | TCP1 |
| NCBI Official Synonym Symbols: | CCT1; CCTa; D6S230E; CCT-alpha; TCP-1-alpha |
| NCBI Protein Information: | T-complex protein 1 subunit alpha; tailless complex polypeptide 1; T-complex protein 1, alpha subunit |
| UniProt Protein Name: | T-complex protein 1 subunit alpha |
| UniProt Synonym Protein Names: | CCT-alpha |
| Protein Family: | T-complex protein |
| UniProt Gene Name: | TCP1 |
| UniProt Entry Name: | TCPA_HUMAN |
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