Epigenetics & Nuclear Signaling Antibodies 2
Anti-TCERG1 Antibody (CAB14850)
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- SKU:
- CAB14850
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-TCERG1 Antibody |
| Antibody SKU: | CAB14850 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 550-650 of human TCERG1 (NP_006697.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HeLa, Jurkat, SW480 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 550-650 of human TCERG1 (NP_006697.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TTRL SMWD RPDD LIGR ADVD KIIQ EPPH KKGM EELK KLRH PTPT MLSI QKWQ FSMS AIKE EQEL MEEI NEDE PVKA KKRK RDDN KDID SEKE AAME AEIK A |
| Gene ID: | 10915 |
| Uniprot: | O14776 |
| Cellular Location: | Nucleus |
| Calculated MW: | 121kDa/123kDa |
| Observed MW: | 160kDa |
| Synonyms: | TCERG1, CA150, TAF2S, Urn1 |
| Background: | This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. |
| UniProt Protein Function: | TCERG1: Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Spliceosome; Transcription factor; RNA-binding Chromosomal Location of Human Ortholog: 5q31 Cellular Component: actin cytoskeleton; nucleolus; nucleus Molecular Function:protein binding; transcription coactivator activity Biological Process: negative regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14776 |
| NCBI GenInfo Identifier: | 158514955 |
| NCBI Gene ID: | 10915 |
| NCBI Accession: | O14776.2 |
| UniProt Secondary Accession: | O14776,Q2NKN2, Q59EA1, |
| UniProt Related Accession: | O14776 |
| Molecular Weight: | 121,690 Da |
| NCBI Full Name: | Transcription elongation regulator 1 |
| NCBI Synonym Full Names: | transcription elongation regulator 1 |
| NCBI Official Symbol: | TCERG1 |
| NCBI Official Synonym Symbols: | Urn1; CA150; TAF2S |
| NCBI Protein Information: | transcription elongation regulator 1 |
| UniProt Protein Name: | Transcription elongation regulator 1 |
| UniProt Synonym Protein Names: | TATA box-binding protein-associated factor 2S; Transcription factor CA150 |
| Protein Family: | Transcription elongation regulator |
| UniProt Gene Name: | TCERG1 |
| UniProt Entry Name: | TCRG1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TCERG1 antibody (CAB14850) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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