Immunology Antibodies 1
Anti-TCEB1 Antibody (CAB12515)
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- SKU:
- CAB12515
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-TCEB1 Antibody |
| Antibody SKU: | CAB12515 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-112 of human TCEB1 (NP_001191791.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat, PC-3, MCF7, HepG2, Mouse liver, Mouse lung, Mouse testis, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-112 of human TCEB1 (NP_001191791.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDGE EKTY GGCE GPDA MYVK LISS DGHE FIVK REHA LTSG TIKA MLSG PGQF AENE TNEV NFRE IPSH VLSK VCMY FTYK VRYT NSST EIPE FPIA PEIA LELL MAAN FLDC |
| Gene ID: | 6921 |
| Uniprot: | Q15369 |
| Cellular Location: | Nucleus |
| Calculated MW: | 10kDa/12kDa |
| Observed MW: | 12kDa |
| Synonyms: | ELOC, SIII, TCEB1, eloC, elongin-C |
| Background: | This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. |
| UniProt Protein Function: | TCEB1: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). Belongs to the SKP1 family. |
| UniProt Protein Details: | Protein type:Transcription initiation complex Chromosomal Location of Human Ortholog: 8q21.11 Cellular Component: cytosol; nucleoplasm Molecular Function:protein binding; ubiquitin-protein ligase activity Biological Process: positive regulation of RNA elongation from RNA polymerase II promoter; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of transcription from RNA polymerase II promoter; RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011] |
| UniProt Code: | Q15369 |
| NCBI GenInfo Identifier: | 32699511 |
| NCBI Gene ID: | 6921 |
| NCBI Accession: | Q15369.1 |
| UniProt Secondary Accession: | Q15369,Q567Q6, E5RGD9, |
| UniProt Related Accession: | Q15369 |
| Molecular Weight: | 10,832 Da |
| NCBI Full Name: | Transcription elongation factor B polypeptide 1 |
| NCBI Synonym Full Names: | transcription elongation factor B subunit 1 |
| NCBI Official Symbol: | TCEB1 |
| NCBI Official Synonym Symbols: | SIII; eloC |
| NCBI Protein Information: | transcription elongation factor B polypeptide 1 |
| UniProt Protein Name: | Transcription elongation factor B polypeptide 1 |
| UniProt Synonym Protein Names: | Elongin 15 kDa subunit; Elongin-C; EloC; RNA polymerase II transcription factor SIII subunit C; SIII p15 |
| Protein Family: | Transcription elongation factor B polypeptide |
| UniProt Gene Name: | TCEB1 |
| UniProt Entry Name: | ELOC_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TCEB1 antibody (CAB12515) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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