Epigenetics & Nuclear Signaling Antibodies 1

Anti-TCEA1 Antibody (CAB10541)

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SKU:
CAB10541
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-TCEA1 Antibody
Antibody SKU:CAB10541
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 80-180 of human TCEA1 (NP_006747.1).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human, Mouse
Positive Samples:U-87MG, 293T, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 80-180 of human TCEA1 (NP_006747.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PSTE KDLD EKKK EPAI TSQN SPEA REES TSSG NVSN RKDE TNAR DTYV SSFP RAPS TSDS VRLK CREM LAAA LRTG DDYI AIGA DEEE LGSQ IEEA IYQE I
Gene ID:6917
Uniprot:P23193
Cellular Location:Nucleus
Calculated MW:31kDa/33kDa
Observed MW:38kDa
Synonyms:TCEA1, GTF2S, SII, TCEA, TF2S, TFIIS
Background:
UniProt Protein Function:TFIIS: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1. Belongs to the TFS-II family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription factor

Chromosomal Location of Human Ortholog: 8q11.23

Cellular Component: nucleolus; nucleoplasm; nucleus; transcription factor TFIID complex

Molecular Function:protein binding

Biological Process: RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair

UniProt Code:P23193
NCBI GenInfo Identifier:1174652
NCBI Gene ID:6917
NCBI Accession:P23193.2
UniProt Secondary Accession:P23193,Q15563, Q6FG87, A6NF25, A8K339,
UniProt Related Accession:P23193
Molecular Weight:34kDa
NCBI Full Name:Transcription elongation factor A protein 1
NCBI Synonym Full Names:transcription elongation factor A1
NCBI Official Symbol:TCEA1  
NCBI Official Synonym Symbols:SII; TCEA; TF2S; GTF2S; TFIIS  
NCBI Protein Information:transcription elongation factor A protein 1
UniProt Protein Name:Transcription elongation factor A protein 1
UniProt Synonym Protein Names:Transcription elongation factor S-II protein 1; Transcription elongation factor TFIIS.o
Protein Family:Tuliposide A-converting enzyme
UniProt Gene Name:TCEA1  
Anti-TCEA1 Antibody (CAB10541)Western blot analysis of extracts of various cell lines, using TCEA1 antibody (CAB10541) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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