Anti-TC10/RHOQ Antibody (CAB19786)

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SKU:
CAB19786
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ARHQ
Synonyms:
HEL-S-42
Synonyms:
RASL7A
Synonyms:
TC10
Synonyms:
TC10A

Description

Product Name:TC10/RHOQ Rabbit mAb
Product Code:CAB19786
Size:20uL, 50uL, 100uL
Synonyms:ARHQ, HEL-S-42, RASL7A, TC10, TC10A
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human TC10/RHOQ
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T, A-549, 22Rv1, Mouse heart, Rat heart
Immunogen:A synthesized peptide derived from human TC10/RHOQ
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:23433
Uniprot:P17081
Calculated MW:25kDa
Observed MW:23KDa
UniProt Protein Function:RHOQ: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia. Belongs to the small GTPase superfamily. Rho family.
UniProt Protein Details:

Protein type:G protein, monomeric; G protein; Motility/polarity/chemotaxis; G protein, monomeric, Rho

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: actin filament; cytosol; plasma membrane

Molecular Function:GBD domain binding; GTPase activity; profilin binding

Biological Process: cellular response to insulin stimulus; cortical actin cytoskeleton organization and biogenesis; GTP metabolic process; insulin receptor signaling pathway; positive regulation of filopodium formation; positive regulation of glucose import; positive regulation of transcription from RNA polymerase II promoter; regulation of actin cytoskeleton organization and biogenesis; regulation of small GTPase mediated signal transduction

NCBI Summary:This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011]
UniProt Code:P17081
NCBI GenInfo Identifier:33440525
NCBI Gene ID:23433
NCBI Accession:BC056154
UniProt Secondary Accession:P17081,Q0VGN1, Q52LS8, Q53SJ1, Q6NS39, Q6P146, Q7Z480 D6W5A6,
UniProt Related Accession:P17081
Molecular Weight:22,659 Da
NCBI Full Name:Homo sapiens ras homolog gene family, member Q, mRNA
NCBI Synonym Full Names:ras homolog family member Q
NCBI Official Symbol:RHOQ  
NCBI Official Synonym Symbols:ARHQ; TC10; TC10A; RASL7A; HEL-S-42  
NCBI Protein Information:rho-related GTP-binding protein RhoQ
UniProt Protein Name:Rho-related GTP-binding protein RhoQ
UniProt Synonym Protein Names:Ras-like protein TC10; Ras-like protein family member 7A
Protein Family:Rho-related GTP-binding protein
UniProt Gene Name:RHOQ  
UniProt Entry Name:RHOQ_HUMAN
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