Epigenetics & Nuclear Signaling Antibodies 3

Anti-TBX6 Antibody (CAB16979)

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SKU:
CAB16979
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-TBX6 Antibody
Antibody SKU:CAB16979
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 191-300 of human TBX6 (NP_004599.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Rat thymus, Rat spleen, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 191-300 of human TBX6 (NP_004599.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SFHR VKLT NSTL DPHG HLIL HSMH KYQP RIHL VRAA QLCS QHWG GMAS FRFP ETTF ISVT AYQN PQIT QLKI AANP FAKG FREN GRNC KRER DARV KRKL RGPE PAAT EA
Gene ID:6911
Uniprot:O95947
Cellular Location:
Calculated MW:33kDa/47kDa
Observed MW:58kDa
Synonyms:TBX6, SCDO5, T-box 6
Background:This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout studies in mice indicate that this gene is important for specification of paraxial mesoderm structures.
UniProt Protein Function:TBX6: T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 16p11.2

Molecular Function:protein binding

Biological Process: anatomical structure morphogenesis; mesoderm development; negative regulation of transcription from RNA polymerase II promoter

Disease: Deafness, Autosomal Recessive 67

NCBI Summary:This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout studies in mice indicate that this gene is important for specification of paraxial mesoderm structures. [provided by RefSeq, Aug 2008]
UniProt Code:O95947
NCBI GenInfo Identifier:115502464
NCBI Gene ID:6911
NCBI Accession:O95947.2
UniProt Secondary Accession:O95947,Q8TAS4, Q9HA44,
UniProt Related Accession:O95947
Molecular Weight:33,197 Da
NCBI Full Name:T-box transcription factor TBX6
NCBI Synonym Full Names:T-box 6
NCBI Official Symbol:TBX6  
NCBI Official Synonym Symbols:SCDO5  
NCBI Protein Information:T-box transcription factor TBX6
UniProt Protein Name:T-box transcription factor TBX6
Protein Family:T-box transcription factor
UniProt Gene Name:TBX6  
UniProt Entry Name:TBX6_HUMAN
Anti-TBX6 Antibody (CAB16979)Western blot analysis of extracts of various cell lines, using TBX6 antibody (CAB16979) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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