Epigenetics & Nuclear Signaling Antibodies 1
Anti-TBX4 Antibody (CAB10691)
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- SKU:
- CAB10691
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-TBX4 Antibody |
| Antibody SKU: | CAB10691 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 296-545 of human TBX4 (NP_060958.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | A-549, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 296-545 of human TBX4 (NP_060958.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | THQA LQHY QHEN GAHS QLAE PQDL PLST FPTQ RDSS LFYH CLKR RDGT RHLD LPCK RSYL EAPS SVGE DHYF RSPP PYDQ QMLS PSYC SEVT PREA CMYS GSGP EIAG VSGV DDLP PPPL SCNM WTSV SPYT SYSV QTME TVPY QPFP THFT ATTM MPRL PTLS AQSS QPPG NAHF SVYN QLSQ SQVR ERGP SASF PRER GLPQ GCER KPPS PHLN AANE FLYS QTFS LSRE SSLQ YHSG MGTV ENWT DG |
| Gene ID: | 9496 |
| Uniprot: | P57082 |
| Cellular Location: | Nucleus |
| Calculated MW: | 60kDa |
| Observed MW: | 60KDa |
| Synonyms: | TBX4, ICPPS, SPS, T-box 4 |
| Background: | This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly this gene, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for this gene in regulating limb development and specification of limb identity. |
| UniProt Protein Function: | TBX4: Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Defects in TBX4 are the cause of small patella syndrome (SPS); also known as ischiopatellar dysplasia or Scott-Taor syndrome. SPS is an autosomal dominant skeletal dysplasia characterized by patellar aplasia or hypoplasia and by anomalies of the pelvis and feet, including disrupted ossification of the ischia and inferior pubic rami. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 17q21-q22 Molecular Function:transcription factor activity Biological Process: limb morphogenesis; skeletal morphogenesis Disease: Small Patella Syndrome |
| NCBI Summary: | This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly this gene, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for this gene in regulating limb development and specification of limb identity. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P57082 |
| NCBI GenInfo Identifier: | 51338786 |
| NCBI Gene ID: | 9496 |
| NCBI Accession: | P57082.2 |
| UniProt Secondary Accession: | P57082,A5PKU7, B2RMT1, B7ZLV3, |
| UniProt Related Accession: | P57082 |
| Molecular Weight: | 60,275 Da |
| NCBI Full Name: | T-box transcription factor TBX4 |
| NCBI Synonym Full Names: | T-box 4 |
| NCBI Official Symbol: | TBX4 |
| NCBI Official Synonym Symbols: | SPS; ICPPS |
| NCBI Protein Information: | T-box transcription factor TBX4 |
| UniProt Protein Name: | T-box transcription factor TBX4 |
| Protein Family: | T-box transcription factor |
| UniProt Gene Name: | TBX4 |
| UniProt Entry Name: | TBX4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TBX4 antibody (CAB10691) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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