Name: Anti-TBX22 Antibody (CAB7801)
Brand: Epigenetics & Nuclear Signaling Antibodies 4
SKU: CAB7801
Availability: OutOfStock

Antibody Name:	Anti-TBX22 Antibody
Antibody SKU:	CAB7801
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 291-520 of human TBX22 (NP_058650.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	HeLa, Mouse testis

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 291-520 of human TBX22 (NP_058650.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	LDGL LETY PWRP SFTL DFKT FGAD TQSG SSGS SPVT SSGG APSP LNSL LSPL CFSP MFHL PTSS LGMP CPEA YLPN VNLP LCYK ICPT NFWQ QQPL VLPA PERL ASSN SSQS LAPL MMEV PMLS SLGV TNSK SGSS EDSS DQYL QAPN STNQ MLYG LQSP GNIF LPNS ITPE ALSC SFHP SYDF YRYN FSMP SRLI SGSN HLKV NDDS QVSF GEGK CNHV HWYP AINH YL
Gene ID:	50945
Uniprot:	Q9Y458
Cellular Location:	Nucleus
Calculated MW:	44kDa/57kDa
Observed MW:	55kDa

Synonyms:

TBX22, ABERS, CLPA, CPX, TBXX, dJ795G23.1, T-box 22

Background:

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, Cleft palate with ankyloglossia, and it is believed to play a major role in human palatogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

UniProt Protein Function:	TBX22: Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis. Defects in TBX22 are the cause of X-linked cleft palate with ankyloglossia (CPX). 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:DNA-binding Chromosomal Location of Human Ortholog: Xq21.1 Cellular Component: nucleus Molecular Function:DNA binding; transcription factor activity Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent Disease: Cleft Palate With Or Without Ankyloglossia, X-linked; Abruzzo-erickson Syndrome
NCBI Summary:	This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, Cleft palate with ankyloglossia, and it is believed to play a major role in human palatogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9Y458
NCBI GenInfo Identifier:	28381405
NCBI Gene ID:	50945
NCBI Accession:	Q9Y458.3
UniProt Secondary Accession:	Q9Y458,Q5JZ06, Q96LC0, Q9HBF1,
UniProt Related Accession:	Q9Y458
Molecular Weight:	520
NCBI Full Name:	T-box transcription factor TBX22
NCBI Synonym Full Names:	T-box 22
NCBI Official Symbol:	TBX22
NCBI Official Synonym Symbols:	CPX; CLPA; TBXX; ABERS; dJ795G23.1
NCBI Protein Information:	T-box transcription factor TBX22; T-box protein 22
UniProt Protein Name:	T-box transcription factor TBX22
Protein Family:	T-box transcription factor
UniProt Gene Name:	TBX22
UniProt Entry Name:	TBX22_HUMAN

Western blot analysis of extracts of various cell lines, using TBX22 antibody (CAB7801) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

Antibodies

TBX22 Antibody (PACO04514)

TBX22 Antibody (PACO12660)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)