Epigenetics & Nuclear Signaling Antibodies 3

Anti-TBX21 Antibody (CAB4682)

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SKU:
CAB4682
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
TBX21
Synonyms:
T-PET
Synonyms:
T-bet
Synonyms:
TBET
Synonyms:
TBLYM
Synonyms:
T-box 21
Research Area:
Epigenetics and Nuclear Signaling

Description

Product Name:TBX21 Rabbit pAb
Product Code:CAB4682
Size:20uL, 50uL, 100uL
Synonyms:TBX21, T-PET, T-bet, TBET, TBLYM, T-box 21
Applications:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 326-535 of human TBX21 (NP_037483.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:1000
Reactivity:Human, Rat
Positive Samples:B cells
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 326-535 of human TBX21 (NP_037483.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ENFE SMYT SVDT SIPS PPGP NCQF LGGD HYSP LLPN QYPV PSRF YPDL PGQA KDVV PQAY WLGA PRDH SYEA EFRA VSMK PAFL PSAP GPTM SYYR GQEV LAPG AGWP VAPQ YPPK MGPA SWFR PMRT LPME PGPG GSEG RGPE DQGP PLVW TEIA PIRP ESSD SGLG EGDS KRRR VSPY PSSG DSSS PAGA PSPF DKEA EGQF YNYF PN
Gene ID:30009
Uniprot:Q9UL17
Cellular Location:Nucleus
Calculated MW:58kDa
Observed MW:58kDa
UniProt Protein Function:TBX21: Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs. T-cell specific.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: cell soma; nucleus

Molecular Function:transcription factor activity

Biological Process: positive regulation of isotype switching to IgG isotypes; transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to virus; positive regulation of transcription, DNA-dependent; multicellular organismal development; T cell differentiation

Disease: Asthma, Nasal Polyps, And Aspirin Intolerance

NCBI Summary:This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UL17
NCBI GenInfo Identifier:12230772
NCBI Gene ID:30009
NCBI Accession:Q9UL17.1
UniProt Related Accession:Q9UL17
Molecular Weight:58,328 Da
NCBI Full Name:T-box transcription factor TBX21
NCBI Synonym Full Names:T-box 21
NCBI Official Symbol:TBX21  
NCBI Official Synonym Symbols:TBET; T-PET; T-bet; TBLYM  
NCBI Protein Information:T-box transcription factor TBX21; T-box protein 21; T-box expressed in T cells; transcription factor TBLYM; T-cell-specific T-box transcription factor T-bet
UniProt Protein Name:T-box transcription factor TBX21
UniProt Synonym Protein Names:T-cell-specific T-box transcription factor T-bet; Transcription factor TBLYM
Protein Family:T-box transcription factor
UniProt Gene Name:TBX21  
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