Cell Cycle Antibodies 2

Anti-TBRG1 Antibody (CAB7164)

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SKU:
CAB7164
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-TBRG1 Antibody
Antibody SKU:CAB7164
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-150 of human TBRG1 (NP_116200.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HL-60, SKOV3
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-150 of human TBRG1 (NP_116200.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MKKL PKKS QNEK YRLK YLRL RKAA KATV FENA AICD EIAR LEEK FLKA KEER RYLL KKLL QLQA LTEG EVQA AAPS HSSS LPLT YGVA SSVG TIQG AGPI SGPS TGAE EPFG KKTK KEKK EKGK ENNK L
Gene ID:84897
Uniprot:Q3YBR2
Cellular Location:Nucleus
Calculated MW:20kDa/29kDa/44kDa
Observed MW:45kDa
Synonyms:TBRG1, NIAM, TB-5
Background:
UniProt Protein Function:TBRG1: Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. Belongs to the TBRG1 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Tumor suppressor

Chromosomal Location of Human Ortholog: 11q24.2

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; nucleus

Molecular Function:protein binding

Biological Process: negative regulation of cell proliferation; nucleolus to nucleoplasm transport; protein stabilization; DNA replication; cell cycle arrest

UniProt Code:Q3YBR2
NCBI GenInfo Identifier:121943045
NCBI Gene ID:84897
NCBI Accession:Q3YBR2.1
UniProt Related Accession:Q3YBR2
Molecular Weight:29kDa
NCBI Full Name:Transforming growth factor beta regulator 1
NCBI Synonym Full Names:transforming growth factor beta regulator 1
NCBI Official Symbol:TBRG1  
NCBI Official Synonym Symbols:NIAM; TB-5  
NCBI Protein Information:transforming growth factor beta regulator 1
UniProt Protein Name:Transforming growth factor beta regulator 1
UniProt Synonym Protein Names:Nuclear interactor of ARF and Mdm2
Protein Family:Transforming growth factor
UniProt Gene Name:TBRG1  
UniProt Entry Name:TBRG1_HUMAN
Anti-TBRG1 Antibody (CAB7164)Western blot analysis of extracts of various cell lines, using TBRG1 antibody (CAB7164) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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