Epigenetics & Nuclear Signaling Antibodies 4

Anti-TBPL1 Antibody (CAB7575)

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SKU:
CAB7575
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-TBPL1 Antibody
Antibody SKU:CAB7575
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-186 of human TBPL1 (NP_004856.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-186 of human TBPL1 (NP_004856.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDAD SDVA LDIL ITNV VCVF RTRC HLNL RKIA LEGA NVIY KRDV GKVL MKLR KPRI TATI WSSG KIIC TGAT SEEE AKFG ARRL ARSL QKLG FQVI FTDF KVVN VLAV CNMP FEIR LPEF TKNN RPHA SYEP ELHP AVCY RIKS LRAT LQIF STGS ITVT GPNV KAVA TAVE QIYP FVFE SRKE IL
Gene ID:9519
Uniprot:P62380
Cellular Location:Cytoplasm, Nucleus
Calculated MW:20kDa
Observed MW:21kDa
Synonyms:TBPL1, MGC:8389, MGC:9620, STUD, TLF, TLP, TRF2
Background:This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3.
UniProt Protein Function:TBPL1: Does not bind the TATA box. Has DNA-binding ability. Belongs to the TBP family.
UniProt Protein Details:

Protein type:Cell development/differentiation; DNA-binding; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 6q23.2

Cellular Component: cytoplasm; transcription factor TFIIA complex

Molecular Function:DNA binding; transcription coactivator activity

Biological Process: acrosome formation; transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription initiation; spermatid nuclear differentiation; dTTP biosynthetic process

NCBI Summary:This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Nov 2011]
UniProt Code:P62380
NCBI GenInfo Identifier:358439409
NCBI Gene ID:9519
NCBI Accession:NP_001240605
UniProt Related Accession:P62380
Molecular Weight:
NCBI Full Name:TATA box-binding protein-like protein 1
NCBI Synonym Full Names:TATA-box binding protein like 1
NCBI Official Symbol:TBPL1  
NCBI Official Synonym Symbols:TLF; TLP; STUD; TRF2; MGC:8389; MGC:9620  
NCBI Protein Information:TATA box-binding protein-like protein 1
UniProt Protein Name:TATA box-binding protein-like protein 1
UniProt Synonym Protein Names:21 kDa TBP-like protein; Second TBP of unique DNA protein; STUD; TATA box-binding protein-related factor 2; TBP-related factor 2; TBP-like factor; TBP-related protein
Protein Family:Protein
UniProt Gene Name:TBPL1  
UniProt Entry Name:TBPL1_HUMAN
Anti-TBPL1 Antibody (CAB7575)Western blot analysis of extracts of 293T cells, using TBPL1 antibody (CAB7575) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-TBPL1 Antibody (CAB7575)Immunofluorescence analysis of A549 cells using TBPL1 antibody (CAB7575). Blue: DAPI for nuclear staining.
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