Immunology Antibodies 2
Anti-TBK1 Antibody (CAB2573)
- SKU:
- CAB2573
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-TBK1 Antibody |
| Antibody SKU: | CAB2573 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 440-729 of human TBK1 (NP_037386.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 440-729 of human TBK1 (NP_037386.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RKGI RWLI ELIK DDYN ETVH KKTE VVIT LDFC IRNI EKTV KVYE KLMK INLE AAEL GEIS DIHT KLLR LSSS QGTI ETSL QDID SRLS PGGS LADA WAHQ EGTH PKDR NVEK LQVL LNCM TEIY YQFK KDKA ERRL AYNE EQIH KFDK QKLY YHAT KAMT HFTD ECVK KYEA FLNK SEEW IRKM LHLR KQLL SLTN QCFD IEEE VSKY QEYT NELQ ETLP QKMF TASS GIKH TMTP IYPS SNTL VEMT LGMK KLKE EMEG VVKE LAEN NHIL ERFG SLTM DGGL RNVD CL |
| Gene ID: | 29110 |
| Uniprot: | Q9UHD2 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 83kDa |
| Observed MW: | 90kDa |
| Synonyms: | TBK1, FTDALS4, NAK, T2K |
| Background: | The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. |
| UniProt Protein Function: | TBK1: a protein kinase of the IKK family. Can mediate NFkB activation in response to certain growth factors. Forms a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. |
| UniProt Protein Details: | Protein type:Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Other group; IKK family Chromosomal Location of Human Ortholog: 12q14.1 Cellular Component: cytoplasm; endosome membrane; cytosol Molecular Function:protein serine/threonine kinase activity; protein binding; nucleic acid binding; phosphoprotein binding; ATP binding; protein kinase activity Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; MyD88-independent toll-like receptor signaling pathway; response to virus; toll-like receptor 3 signaling pathway; protein amino acid phosphorylation; positive regulation of peptidyl-serine phosphorylation; defense response to Gram-positive bacterium; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon type I production; positive regulation of interferon-beta production; toll-like receptor signaling pathway; interferon type I production; innate immune response; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; negative regulation of interferon type I production; toll-like receptor 4 signaling pathway; defense response to virus; positive regulation of interferon-alpha production Disease: Frontotemporal Dementia And/or Amyotrophic Lateral Sclerosis 4 |
| NCBI Summary: | The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010] |
| UniProt Code: | Q9UHD2 |
| NCBI GenInfo Identifier: | 74761953 |
| NCBI Gene ID: | 29110 |
| NCBI Accession: | Q9UHD2.1 |
| UniProt Secondary Accession: | Q9UHD2,Q8IYV3, Q9NUJ5, A8K4S4, |
| UniProt Related Accession: | Q9UHD2 |
| Molecular Weight: | 83,642 Da |
| NCBI Full Name: | Serine/threonine-protein kinase TBK1 |
| NCBI Synonym Full Names: | TANK-binding kinase 1 |
| NCBI Official Symbol: | TBK1 |
| NCBI Official Synonym Symbols: | NAK; T2K |
| NCBI Protein Information: | serine/threonine-protein kinase TBK1; NF-kB-activating kinase; NF-kappa-B-activating kinase |
| UniProt Protein Name: | Serine/threonine-protein kinase TBK1 |
| UniProt Synonym Protein Names: | NF-kappa-B-activating kinase; T2K; TANK-binding kinase 1 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | TBK1 |
| UniProt Entry Name: | TBK1_HUMAN |
 | Western blot analysis of extracts of Mouse brain, using TBK1 antibody (CAB2573) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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