Signal Transduction Antibodies 2

Anti-TAS2R38 Antibody (CAB15087)

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SKU:
CAB15087
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-TAS2R38 Antibody
Antibody SKU:CAB15087
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 150-250 of human TAS2R38 (NP_789787.4).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:rat thymus
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 150-250 of human TAS2R38 (NP_789787.4).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CSCI CTVL CVWC FFSR PHFT VTTV LFMN NNTR LNWQ IKDL NLFY SFLF CYLW SVPP FLLF LVSS GMLT VSLG RHMR TMKV YTRN SRDP SLEA HIKA LKSL V
Gene ID:5726
Uniprot:P59533
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:37kDa
Observed MW:38kDa
Synonyms:TAS2R38, PTC, T2R38, T2R61
Background:This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant).
UniProt Protein Function:TAS2R38: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. Belongs to the G-protein coupled receptor T2R family.
UniProt Protein Details:

Protein type:Receptor, GPCR; Membrane protein, multi-pass; GPCR, T2R family; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: integral to membrane; plasma membrane

Molecular Function:bitter taste receptor activity

Biological Process: detection of chemical stimulus involved in sensory perception of bitter taste

Disease: Thiourea Tasting

NCBI Summary:This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009]
UniProt Code:P59533
NCBI GenInfo Identifier:68068016
NCBI Gene ID:5726
NCBI Accession:P59533.3
UniProt Secondary Accession:P59533,P59552, Q2M3E8, Q645W3, Q86UK3, A4D1U6,
UniProt Related Accession:P59533
Molecular Weight:37,892 Da
NCBI Full Name:Taste receptor type 2 member 38
NCBI Synonym Full Names:taste 2 receptor member 38
NCBI Official Symbol:TAS2R38  
NCBI Official Synonym Symbols:PTC; T2R38; T2R61  
NCBI Protein Information:taste receptor type 2 member 38
UniProt Protein Name:Taste receptor type 2 member 38
UniProt Synonym Protein Names:PTC bitter taste receptor; Taste receptor type 2 member 61; T2R61
Protein Family:Taste receptor
UniProt Gene Name:TAS2R38  
UniProt Entry Name:T2R38_HUMAN
Anti-TAS2R38 Antibody (CAB15087)Western blot analysis of extracts of rat thymus, using TAS2R38 antibody (CAB15087) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90.
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