Signal Transduction Antibodies 1

Anti-TAS1R1 Antibody (CAB10156)

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SKU:
CAB10156
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-TAS1R1 Antibody
Antibody SKU:CAB10156
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 330-567 of human TAS1R1 (NP_619642.2).
Application:WB
Recommended Dilution:WB 1:1000 - 1:4000
Reactivity:Human, Mouse, Rat
Positive Samples:MCF7, HeLa, Jurkat, Mouse liver, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 330-567 of human TAS1R1 (NP_619642.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AVPG LKAF EEAY ARAD KKAP RPCH KGSW CSSN QLCR ECQA FMAH TMPK LKAF SMSS AYNA YRAV YAVA HGLH QLLG CASG ACSR GRVY PWQL LEQI HKVH FLLH KDTV AFND NRDP LSSY NIIA WDWN GPKW TFTV LGSS TWSP VQLN INET KIQW HGKD NQVP KSVC SSDC LEGH QRVV TGFH HCCF ECVP CGAG TFLN KSDL YRCQ PCGK EEWA PEGS QTCF PRTV VFLA LREH TS
Gene ID:80835
Uniprot:Q7RTX1
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:35kDa/52kDa/65kDa/93kDa
Observed MW:110kDa
Synonyms:TAS1R1, GM148, GPR70, T1R1, TR1
Background:The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.
NCBI Summary:The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
UniProt Code:Q7RTX1
NCBI GenInfo Identifier:57013075
NCBI Gene ID:80835
NCBI Accession:Q7RTX1.1
UniProt Secondary Accession:Q7RTX1,Q5SY22, Q5SY24, Q8NGZ7, Q8TDJ7, Q8TDJ8, Q8TDJ9 Q8TDK0, B2RMX0,
UniProt Related Accession:Q7RTX1
Molecular Weight:35,134 Da
NCBI Full Name:Taste receptor type 1 member 1
NCBI Synonym Full Names:taste 1 receptor member 1
NCBI Official Symbol:TAS1R1  
NCBI Official Synonym Symbols:TR1; T1R1; GM148; GPR70  
NCBI Protein Information:taste receptor type 1 member 1
UniProt Protein Name:Taste receptor type 1 member 1
UniProt Synonym Protein Names:G-protein coupled receptor 70
Protein Family:Taste receptor
UniProt Gene Name:TAS1R1  
UniProt Entry Name:TS1R1_HUMAN
Anti-TAS1R1 Antibody (CAB10156)Western blot analysis of extracts of various cell lines, using TAS1R1 antibody (CAB10156) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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