Epigenetics & Nuclear Signaling Antibodies 4
Anti-TARBP2 Antibody (CAB7533)
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- SKU:
- CAB7533
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-TARBP2 Antibody |
| Antibody SKU: | CAB7533 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-366 of human TARBP2 (NP_599150.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, HepG2, Mouse testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-366 of human TARBP2 (NP_599150.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSEE EQGS GTTT GCGL PSIE QMLA ANPG KTPI SLLQ EYGT RIGK TPVY DLLK AEGQ AHQP NFTF RVTV GDTS CTGQ GPSK KAAK HKAA EVAL KHLK GGSM LEPA LEDS SSFS PLDS SLPE DIPV FTAA AAAT PVPS VVLT RSPP MELQ PPVS PQQS ECNP VGAL QELV VQKG WRLP EYTV TQES GPAH RKEF TMTC RVER FIEI GSGT SKKL AKRN AAAK MLLR VHTV PLDA RDGN EVEP DDDH FSIG VGSR LDGL RNRG PGCT WDSL RNSV GEKI LSLR SCSL GSLG ALGP ACCR VLSE LSEE QAFH VSYL DIEE LSLS GLCQ CLVE LSTQ PATV CHGS ATTR EAAR GEAA RRAL QYLK IMAG SK |
| Gene ID: | 6895 |
| Uniprot: | Q15633 |
| Cellular Location: | Cytoplasm, Nucleus, perinuclear region |
| Calculated MW: | 36kDa/39kDa |
| Observed MW: | 46kDa |
| Synonyms: | TARBP2, LOQS, TRBP, TRBP1, TRBP2 |
| Background: | HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. |
| UniProt Protein Function: | TRBP: the HIV-1 TAR RNA binding protein (TRBP) is a double strand RNA binding protein (dsRBP) that is required for the recruitment of Ago2 to the small interfering RNA (siRNA) bound by Dicer. TRBP increases HIV-1 expression and replication by inhibiting the interferon-induced protein kinase PKR and by increasing translation of viral mRNA. Dicer, Ago2, and TRBP are the main components of the RNA-induced silencing complex (RISC). |
| UniProt Protein Details: | Protein type:Translation; Motility/polarity/chemotaxis; RNA processing; RNA-binding Chromosomal Location of Human Ortholog: 12q13.13 Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytoplasm; nucleus; cytosol Molecular Function:protein binding; siRNA binding; protein homodimerization activity; miRNA binding; double-stranded RNA binding Biological Process: regulation of transcription from RNA polymerase II promoter; regulation of translation; positive regulation of viral genome replication; regulation of transcription, DNA-dependent; pre-microRNA processing; regulation of viral transcription; RNA interference, targeting of mRNA for destruction; miRNA-mediated gene silencing, miRNA loading onto RISC; negative regulation of protein kinase activity; gene expression; negative regulation of defense response to virus by host; RNA interference, production of siRNA |
| NCBI Summary: | HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15633 |
| NCBI GenInfo Identifier: | 209572714 |
| NCBI Gene ID: | 6895 |
| NCBI Accession: | Q15633.3 |
| UniProt Related Accession: | Q15633 |
| Molecular Weight: | 39kDa |
| NCBI Full Name: | RISC-loading complex subunit TARBP2 |
| NCBI Synonym Full Names: | TARBP2 subunit of RISC loading complex |
| NCBI Official Symbol: | TARBP2 |
| NCBI Official Synonym Symbols: | LOQS; TRBP; TRBP1; TRBP2 |
| NCBI Protein Information: | RISC-loading complex subunit TARBP2 |
| UniProt Protein Name: | RISC-loading complex subunit TARBP2 |
| UniProt Synonym Protein Names: | TAR RNA-binding protein 2; Trans-activation-responsive RNA-binding protein |
| UniProt Gene Name: | TARBP2 |
| UniProt Entry Name: | TRBP2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TARBP2 antibody (CAB7533) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human thyroid cancer using TARBP2 Rabbit pAb (CAB7533) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human breast cancer using TARBP2 Rabbit pAb (CAB7533) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of A549 cells using TARBP2 antibody (CAB7533). |
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