Cell Biology Antibodies 18

Anti-TAPBPL Antibody (CAB18294)

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SKU:
CAB18294
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TAPBPL Antibody
Antibody SKU:CAB18294
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human TAPBPL.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant protein of human TAPBPL.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:55080
Uniprot:Q9BX59
Cellular Location:
Calculated MW:50kDa
Observed MW:Refer to figures
Synonyms:TAPBPR, TAPBP-R, TAPBPL
Background:Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.
UniProt Protein Function:TAPBPL: Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2- microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression. {ECO:0000269|PubMed:23401559}. Induced by interferon gamma. {ECO:0000269|PubMed:23401559}. 7 isoforms of the human protein are produced by alternative splicing
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.31

Molecular Function:protein complex binding

Biological Process: negative regulation of antigen processing and presentation of peptide antigen via MHC class I

NCBI Summary:Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.[supplied by OMIM, Mar 2008]
UniProt Code:Q9BX59
NCBI GenInfo Identifier:296452847
NCBI Gene ID:55080
NCBI Accession:Q9BX59.2
UniProt Secondary Accession:Q9BX59,Q9NWB8,
UniProt Related Accession:Q9BX59
Molecular Weight:55,092 Da
NCBI Full Name:Tapasin-related protein
NCBI Synonym Full Names:TAP binding protein like
NCBI Official Symbol:TAPBPL  
NCBI Official Synonym Symbols:TAPBPR; TAPBP-R  
NCBI Protein Information:tapasin-related protein
UniProt Protein Name:Tapasin-related protein
UniProt Synonym Protein Names:TAP-binding protein-like; TAP-binding protein-related protein; TAPBP-R; Tapasin-like
Protein Family:Tapasin-related protein
UniProt Gene Name:TAPBPL  
UniProt Entry Name:TPSNR_HUMAN
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