Cell Biology Antibodies 18
Anti-TAPBPL Antibody (CAB18294)
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- SKU:
- CAB18294
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TAPBPL Antibody |
| Antibody SKU: | CAB18294 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human TAPBPL. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant protein of human TAPBPL. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 55080 |
| Uniprot: | Q9BX59 |
| Cellular Location: | |
| Calculated MW: | 50kDa |
| Observed MW: | Refer to figures |
| Synonyms: | TAPBPR, TAPBP-R, TAPBPL |
| Background: | Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC. |
| UniProt Protein Function: | TAPBPL: Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2- microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression. {ECO:0000269|PubMed:23401559}. Induced by interferon gamma. {ECO:0000269|PubMed:23401559}. 7 isoforms of the human protein are produced by alternative splicing |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12p13.31 Molecular Function:protein complex binding Biological Process: negative regulation of antigen processing and presentation of peptide antigen via MHC class I |
| NCBI Summary: | Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9BX59 |
| NCBI GenInfo Identifier: | 296452847 |
| NCBI Gene ID: | 55080 |
| NCBI Accession: | Q9BX59.2 |
| UniProt Secondary Accession: | Q9BX59,Q9NWB8, |
| UniProt Related Accession: | Q9BX59 |
| Molecular Weight: | 55,092 Da |
| NCBI Full Name: | Tapasin-related protein |
| NCBI Synonym Full Names: | TAP binding protein like |
| NCBI Official Symbol: | TAPBPL |
| NCBI Official Synonym Symbols: | TAPBPR; TAPBP-R |
| NCBI Protein Information: | tapasin-related protein |
| UniProt Protein Name: | Tapasin-related protein |
| UniProt Synonym Protein Names: | TAP-binding protein-like; TAP-binding protein-related protein; TAPBP-R; Tapasin-like |
| Protein Family: | Tapasin-related protein |
| UniProt Gene Name: | TAPBPL |
| UniProt Entry Name: | TPSNR_HUMAN |
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