Epigenetics & Nuclear Signaling Antibodies 3
Anti-TAOK3 Antibody (CAB17345)
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- SKU:
- CAB17345
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-TAOK3 Antibody |
| Antibody SKU: | CAB17345 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human TAOK3. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: |
| Immunogen: | Recombinant protein of human TAOK3. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 51347 |
| Uniprot: | Q9H2K8 |
| Cellular Location: | |
| Calculated MW: | 105kDa |
| Observed MW: | Refer to figures |
| Synonyms: | TAOK3, DPK, JIK, MAP3K18, hKFC-A, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CDW44, CSPG8, HCELL, HUTCH-I, ECMR-III |
| Background: | The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. |
| UniProt Protein Function: | TAO3: Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. |
| UniProt Protein Details: | Protein type:EC 2.7.11.1; Protein kinase, STE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; TAO subfamily Chromosomal Location of Human Ortholog: 12q Cellular Component: cytoplasm Molecular Function:protein binding; protein kinase inhibitor activity; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity; transferase activity Biological Process: MAPKKK cascade; mitotic cell cycle G2/M transition DNA damage checkpoint; negative regulation of JNK cascade; positive regulation of JNK activity; positive regulation of JNK cascade; positive regulation of stress-activated MAPK cascade; protein amino acid autophosphorylation; protein amino acid phosphorylation; response to DNA damage stimulus |
| UniProt Code: | Q9H2K8 |
| NCBI GenInfo Identifier: | 78099183 |
| NCBI Gene ID: | 51347 |
| NCBI Accession: | Q9H2K8.2 |
| UniProt Secondary Accession: | Q9H2K8,Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7, |
| UniProt Related Accession: | Q9H2K8 |
| Molecular Weight: | 105,406 Da |
| NCBI Full Name: | Serine/threonine-protein kinase TAO3 |
| NCBI Synonym Full Names: | TAO kinase 3 |
| NCBI Official Symbol: | TAOK3 |
| NCBI Official Synonym Symbols: | DPK; JIK; MAP3K18 |
| NCBI Protein Information: | serine/threonine-protein kinase TAO3 |
| UniProt Protein Name: | Serine/threonine-protein kinase TAO3 |
| UniProt Synonym Protein Names: | Cutaneous T-cell lymphoma-associated antigen HD-CL-09; CTCL-associated antigen HD-CL-09; Dendritic cell-derived protein kinase; JNK/SAPK-inhibitory kinase; Jun kinase-inhibitory kinase; Kinase from chicken homolog A; hKFC-A; Thousand and one amino acid protein 3 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | TAOK3 |
| UniProt Entry Name: | TAOK3_HUMAN |
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