Metabolism Antibodies 2

Anti-TALDO1 Antibody (CAB6762)

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SKU:
CAB6762
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-TALDO1 Antibody
Antibody SKU:CAB6762
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-337 of human TALDO1 (NP_006746.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:10 - 1:100
Reactivity:Human, Mouse
Positive Samples:A-431, SW480, Mouse brain, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-337 of human TALDO1 (NP_006746.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSSS PVKR QRME SALD QLKQ FTTV VADT GDFH AIDE YKPQ DATT NPSL ILAA AQMP AYQE LVEE AIAY GRKL GGSQ EDQI KNAI DKLF VLFG AEIL KKIP GRVS TEVD ARLS FDKD AMVA RARR LIEL YKEA GISK DRIL IKLS STWE GIQA GKEL EEQH GIHC NMTL LFSF AQAV ACAE AGVT LISP FVGR ILDW HVAN TDKK SYEP LEDP GVKS VTKI YNYY KKFS YKTI VMGA SFRN TGEI KALA GCDF LTIS PKLL GELL QDNA KLVP VLSA KAAQ ASDL EKIH LDEK SFRW LHNE DQMA VEKL SDGI RKFA ADAV KLER MLTE RMFN AENG K
Gene ID:6888
Uniprot:P37837
Cellular Location:Cytoplasm
Calculated MW:37kDa
Observed MW:38kDa
Synonyms:TALDO1, TAL, TAL-H, TALDOR, TALH
Background:Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis.
UniProt Protein Function:TALDO1: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Defects in TALDO1 are the cause of transaldolase 1 deficiency (TALDO1 deficiency). It results in telangiectases of the skin, hepatosplenomegaly, and enlarged clitoris. Belongs to the transaldolase family. Type 1 subfamily.
UniProt Protein Details:

Protein type:Transferase; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.2.1.2

Chromosomal Location of Human Ortholog: 11p15.5-p15.4

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function:protein binding; transaldolase activity

Biological Process: carbohydrate metabolic process; pentose-phosphate shunt; xylulose biosynthetic process

Disease: Transaldolase Deficiency

NCBI Summary:Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008]
UniProt Code:P37837
NCBI GenInfo Identifier:6648092
NCBI Gene ID:6888
NCBI Accession:P37837.2
UniProt Secondary Accession:P37837,O00751, Q8WV32, Q8WZ45, B2R8M2,
UniProt Related Accession:P37837
Molecular Weight:37,540 Da
NCBI Full Name:Transaldolase
NCBI Synonym Full Names:transaldolase 1
NCBI Official Symbol:TALDO1  
NCBI Official Synonym Symbols:TAL; TALH; TAL-H; TALDOR  
NCBI Protein Information:transaldolase
UniProt Protein Name:Transaldolase
Protein Family:Transaldolase
UniProt Gene Name:TALDO1  
UniProt Entry Name:TALDO_HUMAN
Anti-TALDO1 Antibody (CAB6762)Western blot analysis of extracts of various cell lines, using TALDO1 antibody (CAB6762) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-TALDO1 Antibody (CAB6762)Immunofluorescence analysis of HeLa cells using TALDO1 antibody (CAB6762). Blue: DAPI for nuclear staining.
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