Developmental Biology
Anti-TAL1 Antibody (CAB12927)
- SKU:
- CAB12927
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-TAL1 Antibody |
| Antibody SKU: | CAB12927 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 242-331 of human TAL1 (NP_003180.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | Jurkat, HT-29, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 242-331 of human TAL1 (NP_003180.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LLND QEEE GTQR AKTG KDPV VGAG GGGG GGGG GAPP DDLL QDVL SPNS SCGS SLDG AASP DSYT EEPA PKHT ARSL HPAM LPAA DGAG PR |
| Gene ID: | 6886 |
| Uniprot: | P17542 |
| Cellular Location: | Nucleus |
| Calculated MW: | 16kDa/31kDa/34kDa |
| Observed MW: | 50kDa |
| Synonyms: | TAL1, SCL, TCL5, bHLHa17, tal-1 |
| Background: |
| UniProt Protein Function: | TAL1: a basic helix-loop-helix transcription. Regulates differentiation and survival during hemopoiesis. Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of eryhtroid differentiation. Mutations are associated with T-cell leukemia and melanoma. Binds to the LIM domain containing protein Rhombotin-2. |
| UniProt Protein Details: | Protein type:DNA-binding; Oncoprotein; Transcription factor Chromosomal Location of Human Ortholog: 1p32 Cellular Component: histone deacetylase complex; nuclear chromatin; nucleus; transcription factor complex Molecular Function:chromatin binding; enzyme binding; histone deacetylase binding; protein binding; transcription factor activity Biological Process: basophil differentiation; cell fate commitment; embryonic hemopoiesis; erythrocyte differentiation; hemopoiesis; megakaryocyte differentiation; positive regulation of cell division; positive regulation of chromatin assembly or disassembly; positive regulation of erythrocyte differentiation; positive regulation of mitotic cell cycle; positive regulation of protein complex assembly; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter Disease: Leukemia, Acute Lymphoblastic |
| UniProt Code: | P17542 |
| NCBI GenInfo Identifier: | 134305 |
| NCBI Gene ID: | 6886 |
| NCBI Accession: | P17542.2 |
| UniProt Secondary Accession: | P17542,D3DQ24, |
| UniProt Related Accession: | P17542 |
| Molecular Weight: | 16,548 Da |
| NCBI Full Name: | T-cell acute lymphocytic leukemia protein 1 |
| NCBI Synonym Full Names: | TAL bHLH transcription factor 1, erythroid differentiation factor |
| NCBI Official Symbol: | TAL1 |
| NCBI Official Synonym Symbols: | SCL; TCL5; tal-1; bHLHa17 |
| NCBI Protein Information: | T-cell acute lymphocytic leukemia protein 1 |
| UniProt Protein Name: | T-cell acute lymphocytic leukemia protein 1 |
| UniProt Synonym Protein Names: | Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia/lymphoma protein 5 |
| Protein Family: | Transaldolase |
| UniProt Gene Name: | TAL1 |
| UniProt Entry Name: | TAL1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TAL1 antibody (CAB12927) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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