Cell Biology Antibodies 10
Anti-TAGLN Antibody (CAB6760)
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- SKU:
- CAB6760
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TAGLN Antibody |
| Antibody SKU: | CAB6760 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-201 of human TAGLN (NP_001001522.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:10 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, Mouse heart, Mouse kidney, Rat kidney, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-201 of human TAGLN (NP_001001522.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MANK GPSY GMSR EVQS KIEK KYDE ELEE RLVE WIIV QCGP DVGR PDRG RLGF QVWL KNGV ILSK LVNS LYPD GSKP VKVP ENPP SMVF KQME QVAQ FLKA AEDY GVIK TDMF QTVD LFEG KDMA AVQR TLMA LGSL AVTK NDGH YRGD PNWF MKKA QEHK REFT ESQL QEGK HVIG LQMG SNRG ASQA GMTG YGRP RQII S |
| Gene ID: | 6876 |
| Uniprot: | Q01995 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 22kDa |
| Observed MW: | 20kDa |
| Synonyms: | TAGLN, SM22, SMCC, TAGLN1, WS3-10 |
| Background: | The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene. |
| UniProt Protein Function: | TAGLN: Actin cross-linking/gelling protein. Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence. Belongs to the calponin family. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Actin-binding; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q23.2 Molecular Function:protein binding Biological Process: epithelial cell differentiation; muscle development |
| NCBI Summary: | The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q01995 |
| NCBI GenInfo Identifier: | 3123283 |
| NCBI Gene ID: | 6876 |
| NCBI Accession: | Q01995.4 |
| UniProt Secondary Accession: | Q01995,O15542, |
| UniProt Related Accession: | Q01995 |
| Molecular Weight: | 22,611 Da |
| NCBI Full Name: | Transgelin |
| NCBI Synonym Full Names: | transgelin |
| NCBI Official Symbol: | TAGLN |
| NCBI Official Synonym Symbols: | SM22; SMCC; TAGLN1; WS3-10 |
| NCBI Protein Information: | transgelin |
| UniProt Protein Name: | Transgelin |
| UniProt Synonym Protein Names: | 22 kDa actin-binding protein; Protein WS3-10; Smooth muscle protein 22-alpha; SM22-alpha |
| Protein Family: | Transgelin |
| UniProt Gene Name: | TAGLN |
| UniProt Entry Name: | TAGL_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TAGLN antibody (CAB6760) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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