Epigenetics & Nuclear Signaling Antibodies 2

Anti-TAF9B Antibody (CAB15846)

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SKU:
CAB15846
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-TAF9B Antibody
Antibody SKU:CAB15846
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human TAF9B (NP_057059.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human TAF9B (NP_057059.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ILDD AKIY SSHA KKPN VDAD DVRL AIQC RADQ SFTS PPPR DFLL DIAR QKNQ TPLP LIKP YAGP RLPP DRYC LTAP NYRL KSLI KKGP NQGR LVPR LSVG A
Gene ID:51616
Uniprot:Q9HBM6
Cellular Location:Nucleus
Calculated MW:27kDa
Observed MW:28kDa
Synonyms:TAF9B, DN-7, DN7, TAF9L, TAFII31L, TFIID-31
Background:Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process.
UniProt Protein Function:TAF9B: Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. Belongs to the TAF9 family.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: Xq13.1-q21.1

Cellular Component: nucleoplasm; transcription factor TFIID complex

Molecular Function:protein binding; transcription corepressor activity

Biological Process: negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell growth; protein stabilization; RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter

NCBI Summary:Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process. [provided by RefSeq, Jul 2008]
UniProt Code:Q9HBM6
NCBI GenInfo Identifier:74752778
NCBI Gene ID:51616
NCBI Accession:Q9HBM6.1
UniProt Secondary Accession:Q9HBM6,Q9Y2S3, B2RUZ9,
UniProt Related Accession:Q9HBM6
Molecular Weight:27,622 Da
NCBI Full Name:Transcription initiation factor TFIID subunit 9B
NCBI Synonym Full Names:TATA-box binding protein associated factor 9b
NCBI Official Symbol:TAF9B  
NCBI Official Synonym Symbols:DN7; DN-7; TAF9L; TAFII31L; TFIID-31  
NCBI Protein Information:transcription initiation factor TFIID subunit 9B
UniProt Protein Name:Transcription initiation factor TFIID subunit 9B
UniProt Synonym Protein Names:Neuronal cell death-related protein 7; DN-7; Transcription initiation factor TFIID subunit 9-like; Transcription-associated factor TAFII31L
Protein Family:Transcription initiation factor
UniProt Gene Name:TAF9B  
UniProt Entry Name:TAF9B_HUMAN
Anti-TAF9B Antibody (CAB15846)Western blot analysis of extracts of HeLa cells, using TAF9B antibody (CAB15846) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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