Epigenetics & Nuclear Signaling Antibodies 2
Anti-TAF9B Antibody (CAB15845)
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- SKU:
- CAB15845
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-TAF9B Antibody |
| Antibody SKU: | CAB15845 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human TAF9B (NP_057059.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse kidney, Mouse liver |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human TAF9B (NP_057059.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ILDD AKIY SSHA KKPN VDAD DVRL AIQC RADQ SFTS PPPR DFLL DIAR QKNQ TPLP LIKP YAGP RLPP DRYC LTAP NYRL KSLI KKGP NQGR LVPR LSVG A |
| Gene ID: | 51616 |
| Uniprot: | Q9HBM6 |
| Cellular Location: | Nucleus |
| Calculated MW: | 27kDa |
| Observed MW: | 28kDa |
| Synonyms: | TAF9B, DN-7, DN7, TAF9L, TAFII31L, TFIID-31 |
| Background: | Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process. |
| UniProt Protein Function: | TAF9B: Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. Belongs to the TAF9 family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: Xq13.1-q21.1 Cellular Component: nucleoplasm; transcription factor TFIID complex Molecular Function:protein binding; transcription corepressor activity Biological Process: negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell growth; protein stabilization; RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter |
| NCBI Summary: | Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9HBM6 |
| NCBI GenInfo Identifier: | 74752778 |
| NCBI Gene ID: | 51616 |
| NCBI Accession: | Q9HBM6.1 |
| UniProt Secondary Accession: | Q9HBM6,Q9Y2S3, B2RUZ9, |
| UniProt Related Accession: | Q9HBM6 |
| Molecular Weight: | 27,622 Da |
| NCBI Full Name: | Transcription initiation factor TFIID subunit 9B |
| NCBI Synonym Full Names: | TATA-box binding protein associated factor 9b |
| NCBI Official Symbol: | TAF9B |
| NCBI Official Synonym Symbols: | DN7; DN-7; TAF9L; TAFII31L; TFIID-31 |
| NCBI Protein Information: | transcription initiation factor TFIID subunit 9B |
| UniProt Protein Name: | Transcription initiation factor TFIID subunit 9B |
| UniProt Synonym Protein Names: | Neuronal cell death-related protein 7; DN-7; Transcription initiation factor TFIID subunit 9-like; Transcription-associated factor TAFII31L |
| Protein Family: | Transcription initiation factor |
| UniProt Gene Name: | TAF9B |
| UniProt Entry Name: | TAF9B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TAF9B antibody (CAB15845) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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