Cell Biology Antibodies 18

Anti-TAF2 Antibody (CAB18386)

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SKU:
CAB18386
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TAF2 Antibody
Antibody SKU:CAB18386
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human TAF2.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant protein of human TAF2.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6873
Uniprot:Q6P1X5
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:CIF150, MRT40, TAF2B, TAFII150, TAF2
Background:
UniProt Protein Function:TAF2: Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter. Belongs to the TAF2 family.
UniProt Protein Details:

Protein type:Transcription initiation complex

Chromosomal Location of Human Ortholog: 8q24.12

Cellular Component: nucleoplasm; transcription factor TFIID complex

Molecular Function:chromatin binding; protein binding; sequence-specific DNA binding

Biological Process: G2/M transition of mitotic cell cycle; positive regulation of transcription from RNA polymerase II promoter; RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter

Disease: Mental Retardation, Autosomal Recessive 40

NCBI Summary:Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008]
UniProt Code:Q6P1X5
NCBI GenInfo Identifier:145559533
NCBI Gene ID:6873
NCBI Accession:Q6P1X5.3
UniProt Secondary Accession:Q6P1X5,O43487, O43604, O60668, Q86WW7, Q8IWK4, B2RE82
UniProt Related Accession:Q6P1X5
Molecular Weight:136,971 Da
NCBI Full Name:Transcription initiation factor TFIID subunit 2
NCBI Synonym Full Names:TATA-box binding protein associated factor 2
NCBI Official Symbol:TAF2  
NCBI Official Synonym Symbols:MRT40; TAF2B; CIF150; TAFII150  
NCBI Protein Information:transcription initiation factor TFIID subunit 2
UniProt Protein Name:Transcription initiation factor TFIID subunit 2
UniProt Synonym Protein Names:150 kDa cofactor of initiator function; RNA polymerase II TBP-associated factor subunit B; TBP-associated factor 150 kDa; Transcription initiation factor TFIID 150 kDa subunit; TAF(II)150; TAFII-150; TAFII150
Protein Family:Transcription initiation factor
UniProt Gene Name:TAF2  
UniProt Entry Name:TAF2_HUMAN
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