Epigenetics & Nuclear Signaling Antibodies 3

Anti-TAF1B Antibody (CAB14202)

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SKU:
CAB14202
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-TAF1B Antibody
Antibody SKU:CAB14202
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 369-588 of human TAF1B (NP_005671.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 369-588 of human TAF1B (NP_005671.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LFLL DDSF EWSL SNLA EKHN EKNK KDKP WFDF RKWY QIMK KAFD EKKQ KWEE ARAK YLWK SEKP LYYS FVDK PVAY KKRE MVVN LQKQ FSTL VEST ATAG KKSP SSFQ FNWT EEDT DRTC FHGH SLQG VLKE KGQS LLTK NSLY WLST QKFC RCYC THVT TYEE SNYS LSYQ FILN LFSF LLRI KTSL LHEE VSLV EKKL FEKK YSVK RKKS RSKK VRRH
Gene ID:9014
Uniprot:Q53T94
Cellular Location:Nucleus, nucleolus
Calculated MW:39kDa/60kDa/68kDa
Observed MW:Refer to figures
Synonyms:TAF1B, MGC:9349, RAF1B, RAFI63, SL1, TAFI63
Background:Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:TAF1B: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3. Belongs to the RRN7/TAF1B family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Nucleolus; DNA-binding; Transcription initiation complex

Chromosomal Location of Human Ortholog: 2p25

Cellular Component: nucleoplasm

Molecular Function:protein binding; TATA-binding protein binding

Biological Process: positive regulation of gene expression, epigenetic; RNA elongation from RNA polymerase I promoter; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter

NCBI Summary:Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
UniProt Code:Q53T94
NCBI GenInfo Identifier:74726856
NCBI Gene ID:9014
NCBI Accession:Q53T94.1
UniProt Secondary Accession:Q53T94,Q15574, Q8WVC3, B4DI42, F8WD72,
UniProt Related Accession:Q53T94
Molecular Weight:39,533 Da
NCBI Full Name:TATA box-binding protein-associated factor RNA polymerase I subunit B
NCBI Synonym Full Names:TATA-box binding protein associated factor, RNA polymerase I subunit B
NCBI Official Symbol:TAF1B  
NCBI Official Synonym Symbols:SL1; RAF1B; RAFI63; TAFI63; MGC:9349  
NCBI Protein Information:TATA box-binding protein-associated factor RNA polymerase I subunit B
UniProt Protein Name:TATA box-binding protein-associated factor RNA polymerase I subunit B
UniProt Synonym Protein Names:RNA polymerase I-specific TBP-associated factor 63 kDa; TAFI63; TATA box-binding protein-associated factor 1B; TBP-associated factor 1B; Transcription initiation factor SL1/TIF-IB subunit B
Protein Family:Transcription initiation factor
UniProt Gene Name:TAF1B  
UniProt Entry Name:TAF1B_HUMAN
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