Epigenetics & Nuclear Signaling Antibodies 4

Anti-TAF13 Antibody (CAB9637)

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SKU:
CAB9637
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-TAF13 Antibody
Antibody SKU:CAB9637
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-124 of human TAF13 (NP_005636.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:BxPC-3, Mouse pancreas, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-124 of human TAF13 (NP_005636.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MADE EEDP TFEE ENEE IGGG AEGG QGKR KRLF SKEL RCMM YGFG DDQN PYTE SVDI LEDL VIEF ITEM THKA MSIG RQGR VQVE DIVF LIRK DPRK FARV KDLL TMNE ELKR ARKA FDEA NYGS
Gene ID:6884
Uniprot:Q15543
Cellular Location:Nucleus
Calculated MW:14kDa
Observed MW:14kDa
Synonyms:TAF13, TAF(II)18, TAF2K, TAFII-18, TAFII18, MRT60
Background:Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6.
UniProt Protein Function:TAF13: a TBP-associated factor (TAF). A component of TFIID complexes composed of the TATA binding protein (TBP), TAF10 and TAF11. TAF13 and TAF10 contain non-canonical histone folds, forming a histone-like pair in TFIID complexes.
UniProt Protein Details:

Protein type:Translation

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: nucleoplasm; transcription factor TFIID complex; nucleolus; nucleus

Molecular Function:protein C-terminus binding; protein binding; DNA binding; protein heterodimerization activity; transcription cofactor activity; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; viral reproduction; RNA elongation from RNA polymerase II promoter; transcription initiation; gene expression

NCBI Summary:Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6. [provided by RefSeq, Jul 2008]
UniProt Code:Q15543
NCBI GenInfo Identifier:119576759
NCBI Gene ID:6884
NCBI Accession:EAW56355.1
UniProt Secondary Accession:Q15543,Q5TYV6, B2R5E5,
UniProt Related Accession:Q15543
Molecular Weight:14,287 Da
NCBI Full Name:TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa, isoform CRA_a
NCBI Synonym Full Names:TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
NCBI Official Symbol:TAF13  
NCBI Official Synonym Symbols:TAF2K; TAFII18; TAFII-18; TAF(II)18  
NCBI Protein Information:transcription initiation factor TFIID subunit 13; transcription initiation factor TFIID 18 kD subunit; transcription initiation factor TFIID 18 kDa subunit; TATA box binding protein (TBP)-associated factor, RNA polymerase II, K, 18kD
UniProt Protein Name:Transcription initiation factor TFIID subunit 13
UniProt Synonym Protein Names:Transcription initiation factor TFIID 18 kDa subunit
Protein Family:Transcription initiation factor
UniProt Gene Name:TAF13  
UniProt Entry Name:TAF13_HUMAN
Anti-TAF13 Polyclonal Antibody (CAB9637)Western blot analysis of extracts of various cell lines, using TAF13 antibody (CAB9637) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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