Epigenetics & Nuclear Signaling Antibodies 4

Anti-TADA2A Antibody (CAB8457)

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SKU:
CAB8457
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-TADA2A Antibody
Antibody SKU:CAB8457
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-443 of human TADA2A (NP_001159577.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:BT-474, Mouse brain, Mouse skeletal muscle, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-443 of human TADA2A (NP_001159577.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDRL GSFS NDPS DKPP CRGC SSYL MEPY IKCA ECGP PPFF LCLQ CFTR GFEY KKHQ SDHT YEIM TSDF PVLD PSWT AQEE MALL EAVM DCGF GNWQ DVAN QMCT KTKE ECEK HYMK HFIN NPLF ASTL LNLK QAEE AKTA DTAI PFHS TDDP PRPT FDSL LSRD MAGY MPAR ADFI EEFD NYAE WDLR DIDF VEDD SDIL HALK MAVV DIYH SRLK ERQR RKKI IRDH GLIN LRKF QLME RRYP KEVQ DLYE TMRR FARI VGPV EHDK FIES HALE FELR REIK RLQE YRTA GITN FCSA RTYD HLKK TREE ERLK RTML SEVL QYIQ DSSA CQQW LRRQ ADID SGLS PSIP MASN SGRR SAPP LNLT GLPG TEKL NEKE KELC QMVR LVPG AYLE YKSA LLNE CNKQ GGLR LAQA RALI KIDV NKTR KIYD FLIR EGYI TKG
Gene ID:6871
Uniprot:O75478
Cellular Location:Chromosome, Nucleus
Calculated MW:36kDa/51kDa
Observed MW:52kDa
Synonyms:TADA2A, ADA2, ADA2A, KL04P, TADA2L, hADA2
Background:Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined.
UniProt Protein Function:Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling.
NCBI Summary:Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009]
UniProt Code:O75478
NCBI GenInfo Identifier:317373498
NCBI Gene ID:6871
NCBI Accession:O75478.3
UniProt Secondary Accession:O75478,Q9BVJ0, Q9UCW2, Q9UP49, A8MVD0, B3KMU9,
UniProt Related Accession:O75478,AAB50689
Molecular Weight:36,054 Da
NCBI Full Name:Transcriptional adapter 2-alpha
NCBI Synonym Full Names:transcriptional adaptor 2A
NCBI Official Symbol:TADA2A  
NCBI Official Synonym Symbols:ADA2; ADA2A; KL04P; hADA2; TADA2L  
NCBI Protein Information:transcriptional adapter 2-alpha
UniProt Protein Name:Transcriptional adapter 2-alpha
UniProt Synonym Protein Names:Transcriptional adapter 2-like; ADA2-like protein
Protein Family:Transcriptional adapter
UniProt Gene Name:TADA2A  
UniProt Entry Name:TAD2A_HUMAN
Anti-TADA2A Polyclonal Antibody (CAB8457)Western blot analysis of extracts of various cell lines, using TADA2A antibody (CAB8457) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s.
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