Name: Anti-TACR3 Antibody (CAB7220)
Brand: Cell Biology Antibodies 11
SKU: CAB7220
Availability: OutOfStock

Antibody Name:	Anti-TACR3 Antibody
Antibody SKU:	CAB7220
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 356-465 of human TACR3 (NP_001050.1).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	HL-60, Human placenta

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 356-465 of human TACR3 (NP_001050.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	YCCL NKRF RAGF KRAF RWCP FIKV SSYD ELEL KTTR FHPN RQSS MYTV TRME SMTV VFDP NDAD TTRS SRKK RATP RDPS FNGC SRRN SKSA SATS SFIS SPYT SVDE YS
Gene ID:	6870
Uniprot:	P29371
Cellular Location:	Cell membrane, Multi-pass membrane protein
Calculated MW:	52kDa
Observed MW:	52kDa

Synonyms:	TACR3, HH11, NK-3R, NK3R, NKR, TAC3RL
Background:	This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B.

UniProt Protein Function:	TACR3: This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:	Protein type:Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR Chromosomal Location of Human Ortholog: 4q25 Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; nucleus Molecular Function:protein binding; tachykinin receptor activity Biological Process: tachykinin signaling pathway; hyperosmotic salinity response; regulation of dopamine metabolic process; response to morphine; positive regulation of heart rate; response to cocaine; response to estradiol stimulus; positive regulation of blood pressure; aging Disease: Hypogonadotropic Hypogonadism 11 With Or Without Anosmia
NCBI Summary:	This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008]
UniProt Code:	P29371
NCBI GenInfo Identifier:	128364
NCBI Gene ID:	6870
NCBI Accession:	P29371.1
UniProt Secondary Accession:	P29371,Q0P510,
UniProt Related Accession:	P29371
Molecular Weight:	Calculated: 52kDaObserved: 50kDa
NCBI Full Name:	Neuromedin-K receptor
NCBI Synonym Full Names:	tachykinin receptor 3
NCBI Official Symbol:	TACR3
NCBI Official Synonym Symbols:	NKR; HH11; NK3R; NK-3R; TAC3RL
NCBI Protein Information:	neuromedin-K receptor; NK-3 receptor; neurokinin B receptor; neurokinin beta receptor
UniProt Protein Name:	Neuromedin-K receptor
UniProt Synonym Protein Names:	NK-3 receptor; NK-3R; Neurokinin B receptor; Tachykinin receptor 3
Protein Family:	Neuromedin-K receptor
UniProt Gene Name:	TACR3
UniProt Entry Name:	NK3R_HUMAN

	Western blot analysis of extracts of various cell lines, using TACR3 antibody (CAB7220) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
	Immunohistochemistry of paraffin-embedded human stomach cancer using TACR3 antibody (CAB7220) at dilution of 1:100 (40x lens).