Cell Biology Antibodies 8

Anti-TACR2 Antibody (CAB3112)

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SKU:
CAB3112
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TACR2 Antibody
Antibody SKU:CAB3112
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 319-398 of human TACR2 (NP_001048.2).
Application:WB
Recommended Dilution:WB 1:200 - 1:1000
Reactivity:Human
Positive Samples:SGC-7901, A-549
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 319-398 of human TACR2 (NP_001048.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RLAF RCCP WVTP TKED KLEL TPTT SLST RVNR CHTK ETLF MAGD TAPS EATS GEAG RPQD GSGL WFGY GLLA PTKT HVEI
Gene ID:6865
Uniprot:P21452
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:44kDa
Observed MW:44kDa
Synonyms:TACR2, NK2R, NKNAR, SKR, TAC2R
Background:This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A.
UniProt Protein Function:TACR2: This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:substance K receptor activity; protein binding; tachykinin receptor activity

Biological Process: negative regulation of luteinizing hormone secretion; tachykinin signaling pathway; muscle contraction; intestine smooth muscle contraction; operant conditioning; response to electrical stimulus; excretion; positive regulation of vascular permeability; positive regulation of acetylcholine secretion

NCBI Summary:This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008]
UniProt Code:P21452
NCBI GenInfo Identifier:229462950
NCBI Gene ID:6865
NCBI Accession:P21452.3
UniProt Secondary Accession:P21452,Q4QRI5, Q8NGQ8, Q9UDE6, Q9UDE7, A8K7I1,
UniProt Related Accession:P21452
Molecular Weight:398
NCBI Full Name:Substance-K receptor
NCBI Synonym Full Names:tachykinin receptor 2
NCBI Official Symbol:TACR2  
NCBI Official Synonym Symbols:SKR; NK2R; NKNAR; TAC2R  
NCBI Protein Information:substance-K receptor; NK-2R; NK-2 receptor; substance K receptor; neurokinin 2 receptor; neurokinin A receptor; seven transmembrane helix receptor
UniProt Protein Name:Substance-K receptor
UniProt Synonym Protein Names:NK-2 receptor; NK-2R; Neurokinin A receptor; Tachykinin receptor 2
Protein Family:Substance-K receptor
UniProt Gene Name:TACR2  
UniProt Entry Name:NK2R_HUMAN
Anti-TACR2 Antibody (CAB3112)Western blot analysis of extracts of various cell lines, using TACR2 antibody (CAB3112) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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