Cell Biology Antibodies 9
Anti-TACR1 Antibody (CAB5565)
- SKU:
- CAB5565
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TACR1 Antibody |
| Antibody SKU: | CAB5565 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 308-407 of human TACR1 (NP_001049.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HepG2, U-87MG, SGC-996, Mouse heart, Mouse testis, Mouse craniofacial |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 308-407 of human TACR1 (NP_001049.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LNDR FRLG FKHA FRCC PFIS AGDY EGLE MKST RYLQ TQGS VYKV SRLE TTIS TVVG AHEE EPED GPKA TPSS LDLT SNCS SRSD SKTM TESF SFSS NVLS |
| Gene ID: | 6869 |
| Uniprot: | P25103 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 35kDa/46kDa |
| Observed MW: | 40kDa |
| Synonyms: | TACR1, NK1R, NKIR, SPR, TAC1R |
| Background: | This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. |
| UniProt Protein Function: | TACR1: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1 Chromosomal Location of Human Ortholog: 2p12 Cellular Component: cell surface; integral to plasma membrane; cytoplasm; dendrite; plasma membrane Molecular Function:protein binding; substance P receptor activity; tachykinin receptor activity Biological Process: response to nicotine; tachykinin signaling pathway; positive regulation of leukocyte migration; response to morphine; positive regulation of saliva secretion; response to estradiol stimulus; elevation of cytosolic calcium ion concentration; behavioral response to pain; regulation of smooth muscle cell migration; positive regulation of lymphocyte proliferation; positive regulation of stress fiber formation; positive regulation of action potential; inflammatory response; response to electrical stimulus; angiotensin mediated drinking behavior; associative learning; detection of abiotic stimulus; positive regulation of synaptic transmission, cholinergic; regulation of smooth muscle cell proliferation; eating behavior; positive regulation of synaptic transmission, GABAergic; positive regulation of hormone secretion; positive regulation of ossification; positive regulation of vascular permeability; response to ethanol; long-term memory; smooth muscle contraction involved in micturition; response to heat; response to ozone; operant conditioning; positive regulation of vasoconstriction; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); sperm ejaculation; response to progesterone stimulus; acute inflammatory response; positive regulation of blood pressure; positive regulation of epithelial cell proliferation |
| NCBI Summary: | This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008] |
| UniProt Code: | P25103 |
| NCBI GenInfo Identifier: | 128359 |
| NCBI Gene ID: | 6869 |
| NCBI Accession: | P25103.1 |
| UniProt Secondary Accession: | P25103,A8K150, |
| UniProt Related Accession: | P25103 |
| Molecular Weight: | 35,713 Da |
| NCBI Full Name: | Substance-P receptor |
| NCBI Synonym Full Names: | tachykinin receptor 1 |
| NCBI Official Symbol: | TACR1 |
| NCBI Official Synonym Symbols: | SPR; NK1R; NKIR; TAC1R |
| NCBI Protein Information: | substance-P receptor; NK-1R; NK-1 receptor; tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor) |
| UniProt Protein Name: | Substance-P receptor |
| UniProt Synonym Protein Names: | NK-1 receptor; NK-1R; Tachykinin receptor 1 |
| Protein Family: | Substance-P receptor |
| UniProt Gene Name: | TACR1 |
| UniProt Entry Name: | NK1R_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TACR1 antibody (CAB5565) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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