Anti-TACC3 Antibody (CAB19617)
- SKU:
- CAB19617
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ERIC-1
- Synonyms:
- ERIC1
Description
| Product Name: | TACC3 Rabbit mAb |
| Product Code: | CAB19617 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ERIC-1, ERIC1 |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human TACC3 |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T |
| Immunogen: | A synthesized peptide derived from human TACC3 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10460 |
| Uniprot: | Q9Y6A5 |
| Calculated MW: | 140kDa |
| Observed MW: | 140KDa |
| UniProt Protein Function: | TACC3: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May be involved in the control of cell growth and differentiation. May contribute to cancer. Interacts with microtubules. Interacts with CCDC100/CEP120. The coiled coil C-terminus region interacts with AH receptor nuclear translocator protein (ARNT) and ARNT2. Interacts with GCN5L2 and PCAF. Up-regulated in various cancer cell lines. Belongs to the TACC family. |
| UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 4p16.3 Cellular Component: centrosome; cytoplasm Molecular Function:protein domain specific binding; protein binding Biological Process: regulation of microtubule-based process; cell proliferation; cytoplasmic sequestering of transcription factor; astral microtubule organization and biogenesis; neurogenesis; regulation of cell cycle; response to hypoxia; hemopoiesis; microtubule cytoskeleton organization and biogenesis; cerebral cortex development; interkinetic nuclear migration Disease: Bladder Cancer |
| NCBI Summary: | The function of this gene has not yet been determined; however, it is speculated that it may be involved in cell growth and differentiation. Expression of this gene is up-regulated in some cancer cell lines, and in embryonic day 15 in mice. [provided by RefSeq] |
| UniProt Code: | Q9Y6A5 |
| NCBI GenInfo Identifier: | 5454102 |
| NCBI Gene ID: | 10460 |
| NCBI Accession: | NP_006333.1 |
| UniProt Related Accession: | Q2NKK4,Q8IX09,Q9Y6A5 |
| Molecular Weight: | 90,522 Da |
| NCBI Full Name: | transforming acidic coiled-coil-containing protein 3 |
| NCBI Synonym Full Names: | transforming, acidic coiled-coil containing protein 3 |
| NCBI Official Symbol: | TACC3 |
| NCBI Official Synonym Symbols: | ERIC1; ERIC-1; MGC117382; MGC133242 |
| NCBI Protein Information: | transforming acidic coiled-coil-containing protein 3; OTTHUMP00000113796 |
| UniProt Protein Name: | Transforming, acidic coiled-coil containing protein 3 |
| Protein Family: | Transforming acidic coiled-coil-containing protein |
| UniProt Gene Name: | TACC3 |
| UniProt Entry Name: | Q2NKK4_HUMAN |
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