Name: Anti-TAC3 Antibody (CAB6312)
Brand: Cell Biology Antibodies 10
SKU: CAB6312
Availability: OutOfStock

Antibody Name:	Anti-TAC3 Antibody
Antibody SKU:	CAB6312
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-121 of human TAC3 (NP_037383.1).

Application:	WB IF
Recommended Dilution:	WB 1:500 - 1:2000 IF 1:10 - 1:100
Reactivity:	Human, Mouse, Rat
Positive Samples:	Jurkat, Mouse spleen, Mouse brain, Rat kidney, Rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-121 of human TAC3 (NP_037383.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MRIM LLFT AILA FSLA QSFG AVCK EPQE EVVP GGGR SKRD PDLY QLLQ RLFK SHSS LEGL LKAL SQAS TDPK ESTS PEKR DMHD FFVG LMGK RSVQ PDSP TDVN QENV PSFG ILKY PPRA E
Gene ID:	6866
Uniprot:	Q9UHF0
Cellular Location:	Secreted
Calculated MW:	11kDa/13kDa/14kDa
Observed MW:	16kDa

Synonyms:

TAC3, HH10, NKB, NKNB, PRO1155, ZNEUROK1

Background:

This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

UniProt Protein Function:	TAC3: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Belongs to the tachykinin family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 12q13.3 Cellular Component: extracellular region; extracellular space Molecular Function:receptor binding Biological Process: female pregnancy Disease: Hypogonadotropic Hypogonadism 10 With Or Without Anosmia
NCBI Summary:	This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
UniProt Code:	Q9UHF0
NCBI GenInfo Identifier:	18203501
NCBI Gene ID:	6866
NCBI Accession:	Q9UHF0.1
UniProt Secondary Accession:	Q9UHF0,Q6IAG2, Q71BC6, Q71BC9,
UniProt Related Accession:	Q9UHF0
Molecular Weight:	11,358 Da
NCBI Full Name:	Tachykinin-3
NCBI Synonym Full Names:	tachykinin 3
NCBI Official Symbol:	TAC3
NCBI Official Synonym Symbols:	NKB; HH10; NKNB; PRO1155; ZNEUROK1
NCBI Protein Information:	tachykinin-3
UniProt Protein Name:	Tachykinin-3
UniProt Synonym Protein Names:	ZNEUROK1
Protein Family:	Tachykinin
UniProt Gene Name:	TAC3
UniProt Entry Name:	TKNK_HUMAN

Western blot analysis of extracts of various cell lines, using TAC3 antibody (CAB6312) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 20s.

ELISA Kits

Human TAC3 / Tachykinin-3 ELISA Kit

Human Tachykinin-3 (TAC3) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)