Cell Biology Antibodies 15
Anti-TAB3 Antibody (CAB18681)
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- SKU:
- CAB18681
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TAB3 Antibody |
| Antibody SKU: | CAB18681 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human TAB3. |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, Mouse spleen, Mouse heart, Rat testis |
| Immunogen: | Recombinant protein of human TAB3. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 257397 |
| Uniprot: | Q8N5C8 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 100kDa |
 | Western blot - TAB3 Rabbit pAb (CAB18681) |
| Synonyms: | |
| Background: |
| UniProt Protein Function: | TAB3: Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: Xp21.2 Cellular Component: cytoplasm; cytosol; endosome membrane; nucleoplasm; plasma membrane Molecular Function:protein binding Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; I-kappaB kinase/NF-kappaB cascade; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; negative regulation of autophagy; stimulatory C-type lectin receptor signaling pathway |
| NCBI Summary: | The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8N5C8 |
| NCBI GenInfo Identifier: | 229462756 |
| NCBI Gene ID: | 257397 |
| NCBI Accession: | Q8N5C8.2 |
| UniProt Secondary Accession: | Q8N5C8,Q6VQR0, A6NDD9, |
| UniProt Related Accession: | Q8N5C8 |
| Molecular Weight: | 75,599 Da |
| NCBI Full Name: | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 |
| NCBI Synonym Full Names: | TGF-beta activated kinase 1/MAP3K7 binding protein 3 |
| NCBI Official Symbol: | TAB3 |
| NCBI Official Synonym Symbols: | NAP1; MAP3K7IP3 |
| NCBI Protein Information: | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 |
| UniProt Protein Name: | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 |
| UniProt Synonym Protein Names: | Mitogen-activated protein kinase kinase kinase 7-interacting protein 3; NF-kappa-B-activating protein 1; TAK1-binding protein 3; TAB-3; TGF-beta-activated kinase 1-binding protein 3 |
| Protein Family: | TGF-beta-activated kinase 1 and MAP3K7-binding protein |
| UniProt Gene Name: | TAB3 |
| UniProt Entry Name: | TAB3_HUMAN |
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