| UniProt Protein Function: | SYTL4: Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Vesicle Chromosomal Location of Human Ortholog: Xq21.33 Cellular Component: centrosome; cytoplasm; endosome; extrinsic to membrane; nucleoplasm; plasma membrane Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; neurexin binding; phospholipid binding; protein binding; syntaxin binding Biological Process: calcium ion-dependent exocytosis of neurotransmitter; positive regulation of exocytosis; positive regulation of protein secretion; regulation of calcium ion-dependent exocytosis; vesicle fusion |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010] |
| UniProt Code: | Q96C24 |
| NCBI GenInfo Identifier: | 317373281 |
| NCBI Gene ID: | 94121 |
| NCBI Accession: | Q96C24.2 |
| UniProt Secondary Accession: | Q96C24,Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1 |
| UniProt Related Accession: | Q96C24 |
| Molecular Weight: | 39,813 Da |
| NCBI Full Name: | Synaptotagmin-like protein 4 |
| NCBI Synonym Full Names: | synaptotagmin like 4 |
| NCBI Official Symbol: | SYTL4 |
| NCBI Official Synonym Symbols: | SLP4 |
| NCBI Protein Information: | synaptotagmin-like protein 4 |
| UniProt Protein Name: | Synaptotagmin-like protein 4 |
| UniProt Synonym Protein Names: | Exophilin-2; Granuphilin |
| Protein Family: | Synaptotagmin-like protein |
| UniProt Gene Name: | SYTL4 |
| UniProt Entry Name: | SYTL4_HUMAN |
