Cell Biology Antibodies 3

Anti-SYT13 Antibody (CAB12852)

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SKU:
CAB12852
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SYT13 Antibody
Antibody SKU:CAB12852
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 30-180 of human SYT13 (NP_065877.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:U-87MG, Mouse brain, Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 30-180 of human SYT13 (NP_065877.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CRHM HPKK GLLP RDQD PDLE KAKP SLLG SAQQ FNVK KSTE PVQP RALL KFPD IYGP RPAV TAPE VINY ADYS LRST EEPT APAS PQPP NDSR LKRQ VTEE LFIL PQNG VVED VCVM ETWN PEKA ASWN QAPK LHYC LDYD CQKA ELFV TRL
Gene ID:57586
Uniprot:Q7L8C5
Cellular Location:Membrane, Single-pass membrane protein
Calculated MW:46kDa
Observed MW:47kDa
Synonyms:SYT13
Background:This gene encodes a member of the large synaptotagmin protein family. Family members have an extracellular N-terminal transmembrane domain and a cytoplasmic C terminus with two tandem C2 domains (C2A and C2B). Synaptotogmin family members can form homo- and heteromeric complexes with each other. They also have different biochemical properties and developmental profiles, and patterns of tissue distribution. Synaptotagmins function as membrane traffickers in multicellular organisms. Two alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
UniProt Protein Function:SYT13: May be involved in transport vesicle docking to the plasma membrane. Belongs to the synaptotagmin family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Vesicle

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: intracellular membrane-bound organelle; plasma membrane; transport vesicle

Molecular Function:calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; syntaxin binding

Biological Process: calcium ion-dependent exocytosis of neurotransmitter; regulation of calcium ion-dependent exocytosis; vesicle fusion

NCBI Summary:This gene encodes a member of the large synaptotagmin protein family. Family members have an extracellular N-terminal transmembrane domain and a cytoplasmic C terminus with two tandem C2 domains (C2A and C2B). Synaptotogmin family members can form homo- and heteromeric complexes with each other. They also have different biochemical properties and developmental profiles, and patterns of tissue distribution. Synaptotagmins function as membrane traffickers in multicellular organisms. Two alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
UniProt Code:Q7L8C5
NCBI GenInfo Identifier:74749900
NCBI Gene ID:57586
NCBI Accession:Q7L8C5.1
UniProt Secondary Accession:Q7L8C5,Q9BQS3, Q9H041, Q9P2C0, A8K4P4, D3DQP1,
UniProt Related Accession:Q7L8C5
Molecular Weight:47kDa
NCBI Full Name:Synaptotagmin-13
NCBI Synonym Full Names:synaptotagmin 13
NCBI Official Symbol:SYT13  
NCBI Protein Information:synaptotagmin-13
UniProt Protein Name:Synaptotagmin-13
UniProt Synonym Protein Names:Synaptotagmin XIII; SytXIII
Protein Family:Synaptotagmin
UniProt Gene Name:SYT13  
Anti-SYT13 Antibody (CAB12852)Western blot analysis of extracts of various cell lines, using SYT13 antibody (CAB12852) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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